Aggravated, Frustrated, And More

Yesterday I had lunch with two friends who I have known for a very long time. One since the 1970s and the other since the 1980s. While I have sensed over the years they do not understand what I am going through. Yesterday revealed the truth. They do not have a clue. I was so aggravated when I left lunch and I woke up aggravated about it this morning. They were insensitive, self centered, and ignorant of my limitations.I made a lunch reservation and had hoped to be there first so I could get a table with chairs and not a padded bench, which can sometimes be difficult for my back. As my friend, A, was already seated, I decided I wasn't going to make a big deal out of it as the bench seemed okay at first.We chit chatted a few minutes waiting for B to show up. She was late. She is always late. She is incapable of getting anywhere on time. I find this very frustrating because I am limited to how long I can be out with my health issues. She doesn't get it.When B showed up, she told us why she was late: she did text us as she was about to leave but then she had to put everything in her car. Then she realized she forgot her phone so she went back. Finally she realized that she forgot her laptop and, as she was going to work after lunch, she would have to go back and get it. And every statement she makes she knocks her hands on the table so it makes it shake which hurts my back. I just sit with my hands off the table. She always bangs around.Lunch was very good. We took our time so we...
Source: Caroline's Breast Cancer Blog - Category: Cancer & Oncology Tags: aggravation disappointment friends idiots stupidity Source Type: blogs

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Eleven genes have been identified that increase the lifetime risk of developing ovarian cancer. The cumulative cancer risk of ovarian cancer varies with the mutation type and age. Ovarian cancer risk management options include surgical risk reduction with salpingo-oophorectomy and a newer step-wise approach with interval salpingectomy and delayed oophorectomy. Women should be counseled on the pros and cons of hysterectomy in the setting of reducing the risk of other cancers; eliminating the risk of endometrial cancer in Lynch Syndrome, potential risk of serous/serous-like endometrial cancer in BRCA1 carriers, and eliminati...
Source: Clinical Obstetrics and Gynecology - Category: OBGYN Tags: New and Novel Treatments for Gynecologic Cancer Source Type: research
The risk of extra-colonic cancer in IBD is unclear. While thiopurines and tumour necrosis factor- α antagonists (anti-TNFs) are associated with increased risk of skin cancer and lymphoma in IBD, there is scant data on breast cancer in IBD. We evaluated the prevalence of breast cancer in IBD and investigated the role of biologics, immunomodulators, and clinical characteristics of IBD in patients with IBD and breast cancer.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Epidemiology Source Type: research
Contributors : Brooks D Michael ; Zhu YongyouSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThere is substantial evidence that many cancers, including human breast cancer are hierarchically organized and driven by a cellular population that displays stem cell properties. These stem-like cells (CSC ’s) mediate tumor metastasis and by virtue of their relative therapeutic resistance mediate tumor recurrence. Both normal and malignant stem cells are regulated through epigenetic mechanisms which involve DNA and histone modifications as well as noncoding RNAs. However, the mechanisms...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Alexey I Kalinkin ; Alexander S TanasSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensDespite the advantages of neoadjuvant chemotherapy (NACT), associated toxicity is a serious concern and close monitoring of the response of the patients to NACT is required. Thus, prediction of treatment response is imperative to avoid exposure of potential non-responders to deleterious side effects of NACT. We have performed genome-wide analysis of DNA methylation by XmaI-RRBS and selected CpG dinucleotides differential methylation of which discriminates BC samples with different sens...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Homo sapiens Source Type: research
Contributors : Diana E Vel ázquez-Vázquez ; Aylin Del Moral-Morales ; Jenie M Cruz-Burgos ; Eduardo Martínez-Martínez ; Mauricio Rodríguez-Dorantes ; Ignacio Camacho-ArroyoSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiens ; synthetic constructGlioblastoma multiforme (GBM), a grade IV astrocytoma, is the most common and aggressive brain tumor in adults, characterized by being highly infiltrative, angiogenic, and resistant to chemotherapy and radiotherapy. In previous works, has been determined that progesterone P4 increases proliferation, migration and invasion of cell...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens synthetic construct Source Type: research
Publication date: April 2020Source: Biomedicine &Pharmacotherapy, Volume 124Author(s): Bissoli Irene, Muscari ClaudioAbstractAccording to cancer stem cell theory, only a limited number of self-renewing and cloning cells are responsible for tumor relapse after a period of remittance. The aim of the present study was to investigate the effects of Doxorubicin and α-Mangostin, two antiproliferative drugs, on both tumor bulk and stem cells in multicellular tumor spheroids originated from the luminal MCF-7 breast cancer cell line. A new and original fluorimetric assay was used to selectively measure the activity of the...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Background: Women with breast cancer have worse health outcomes with co-occurring type 2 diabetes, possibly due to suboptimal breast cancer treatment. Methods: We created a cohort of women ages 66 to 85 y with stage I to III breast cancer from 1993 to 2012 from an integrated health care delivery system (n=1612) and fee-for-service Medicare beneficiaries (n=98,915), linked to Surveillance, Epidemiology, and End Results (SEER) data (total n=100,527). We evaluated associations between type 2 diabetes and other factors with undergoing guideline-concordant cancer treatment. We estimated χ2 tests for univariate a...
Source: American Journal of Clinical Oncology - Category: Cancer & Oncology Tags: Original Articles: Breast Source Type: research
Publication date: Available online 23 January 2020Source: Cancer CellAuthor(s): Dhivya R. Sudhan, Angel Guerrero-Zotano, Helen Won, Paula González Ericsson, Alberto Servetto, Mariela Huerta-Rosario, Dan Ye, Kyung-min Lee, Luigi Formisano, Yan Guo, Qi Liu, Lisa N. Kinch, Monica Red Brewer, Teresa Dugger, James Koch, Michael J. Wick, Richard E. Cutler, Alshad S. Lalani, Richard Bryce, Alan AuerbachSummaryWe developed neratinib-resistant HER2-mutant cancer cells by gradual dose escalation. RNA sequencing identified TORC1 signaling as an actionable mechanism of drug resistance. Primary and acquired neratinib resistance ...
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Source: Cell Cycle - Category: Cytology Authors: Source Type: research
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