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Allergan reports positive Phase IIb two-year data from liver fibrosis trial

Allergan has reported positive top-line two-year results from its Phase IIb CENTAUR clinical trial of Cenicriviroc (CVC) to treat liver fibrosis in adults suffering from non-alcoholic steatohepatitis (NASH).
Source: Drug Development Technology - Category: Pharmaceuticals Source Type: news

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View Original Article Here: How Long Does Shingles Last In The Elderly? Shingles is a viral infection that follows a varicella-zoster infection, although it can take decades for symptoms of the secondary disease to emerge. The condition presents as a painful and blistering rash, but it is not life-threatening. According to the Center for Disease Control, there are nearly one million cases in the United States each year, and almost half of those cases are in older adults over age 60. Some people only see one instance of the illness, while others have recurring symptoms, but 30 percent of Americans will develop shingles at s...
Source: Shield My Senior - Category: Geriatrics Authors: Tags: Senior Safety Source Type: blogs
When I was in South Africa last year, I met a revolutionary winemaker… His wine was completely organic. It had no toxins, and it contained powerful antioxidant properties. It was infused with a local herb called rooibos, also known as “red bush.” You may have seen rooibos tea on supermarket shelves. I immediately knew this wine should be made widely available in America — and I’m still hopeful a distributor will bring it here. I enjoy a nice glass of red wine from time to time, but the trouble with most of the wines sold in America is that they’re loaded with dangerous chemicals. Winema...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Health additives natural organic Sulfites wine Source Type: news
is the leading cause of prenatal morbidity and some studies showed that prenatal exposure to tobacco smoke is a risk factor for respiratory infections, asthma, allergy, childhood cancer, and it has neurobehavioral consequences regarding children's health.The aims of our studies consist in the assessment of the demographic factors and to evaluate smoking behavior in a group of pregnant women smoking and nonsmoking. Data was collected with the use of a questionnaire, conceived by a primary pulmonologist that assessed multiple risks factors during pregnancy (applied by trained junior doctors under the supervision of qualifie...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tobacco, Smoking Control and Health Education Source Type: research
Conclusion: Second line anti TB drugs are associated with multiple side effects. Comorbidities major intolerance risk. Early management of intolerance is necessary to improve TB prognosis.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research
Conclusion: Our results link transportation noise exposure to development of obesity and suggest that combined exposure from different sources may be particularly harmful. https://doi.org/10.1289/EHP1910 Received: 17 March 2017 Revised: 5 October 2017 Accepted: 9 October 2017 Published: 20 November 2017 Address correspondence to A. Pyko, Institute of Environmental Medicine, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Telephone: 46(0) 852487561. Email: Andrei.pyko@ki.se Supplemental Material is available online (https://doi.org/10.1289/EHP1910). The authors declare they have no actual or potential competing fina...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
ConclusionsWhen topical treatment with calcipotriol fails to improve, or even worsens, existing skin lesions, contact allergy should be suspected. A patch test concentration of 2 µg/ml in isopropyl alcohol seems to be the most suitable. According to the literature, patients sensitized to calcipotriol may tolerate topical therapy with other vitamin D3 analogues, particularly tacalcitol.
Source: Contact Dermatitis - Category: Dermatology Authors: Tags: Original Article Source Type: research
We describe a case of an urticarial reaction to alcoholic beverages.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
Perfumes are products mainly consisting of ethyl alcohol, water and fragrance. These fragrances are responsible for characterizing the pleasant and unique odor of each perfume. Among the fragrances, we highlight a group of fragrances which can cause contact allergy, leading to dermatitis. Brazilian and the European law state that when these concentrations of allergenic fragrances exceed the limit of 0.01% for non-rinse products and 0.001% for products with rinsing, the manufacturer is obliged to discriminate on its label their presence. This work aims to quantify allergic fragrances in original and Brazilian perfume using ...
Source: Journal of the Brazilian Chemical Society - Category: Chemistry Source Type: research
We examined the association between occupational exposure to disinfectants and asthma control in the Nurses' Health Study II, a large cohort of female nurses. Nurses with asthma were invited in 2014 to complete two questionnaires on their current occupation and asthma (response rate 80%). Asthma control was defined by the Asthma Control Test (ACT). Exposure to major disinfectants was evaluated by a job–task–exposure matrix (JTEM). Analyses included 4102 nurses with asthma (mean age 58 years). Asthma control was poor (ACT score 16–19) in 12% of nurses and very poor (ACT score ≤15) in 6% of nurses. ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Epidemiology, occupational and environmental lung disease, Asthma and allergy Original Articles: Asthma and occupational lung disease Source Type: research
A 75-year-old man was referred to a corneal specialist for evaluation of Fuchs corneal dystrophy and cataract. The patient had no significant ocular history, and his medical history was notable for borderline diabetes and hypertension. The patient had no known drug allergies, and his family ocular history was negative. The patient's medications included sodium chloride hypertonicity 5.0% eyedrops (Muro 128) 4 times per day in each eye and lisinopril 20 mg each day. The patient said he does not drink alcohol and denied tobacco or recreational drug use.
Source: Journal of Cataract and Refractive Surgery - Category: Opthalmology Authors: Tags: Consultation section: Cornea Source Type: research
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