Pfizer helps pump $103M into startup to develop new cancer therapies

A local startup has been spun-out of Pfizer to develop clinical-stage experimental therapies. Nascent medicine company SpringWorks Therapeutics completed a $103 million series A round led by the New York-based pharma giant with the help of Bain Capital, OrbiMed and LifeArc (formerly known as MRC Technology). Pfizer (NYSE: PFE) granted SpringWorks the rights to help develop four drugs or t herapies that treat various conditions, including post-traumatic stress disorder and cancer. Another New York-based…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news

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Despite being banned in the 1970s,1 psychedelics are experiencing a cultural renaissance, with growing evidence suggesting compounds like psilocybin, MDMA, LSD, and ketamine may be effective therapies in controlled medical settings.2 Researchers have observed particular benefits for psychedelics in treatment of refractory depression, anxiety, substance addiction (tobacco/alcohol), PTSD, and in palliative care for patients facing terminal cancer.3,4
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Source Type: research
  Answer: No—unless you do it for more than a few months. After a few months, the upfront metabolic and weight benefits will begin to reverse and new health problems arise. We know this with confidence. I raise this question once again because more and more people are coming to me reporting problems. It may take months, even years, but the long-term consequences can be quite serious. Achieving ketosis by engaging in a very low-carbohydrate, high-fat lifestyle is—without a doubt—an effective means of losing weight, breaking insulin and leptin resistance, reversing type 2 diabetes and fatty liver, redu...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: ketones bowel flora ketogenic ketotic undoctored wheat belly Source Type: blogs
Abstract Cognitive activity, manifested as trauma-related ruminative thinking, and deficits in emotional processing are believed to perpetuate the symptoms of posttraumatic stress disorder (PTSD). The aim of this study was to determine the mediating role of rumination in the relationship between emotional processing difficulties and PTSD symptoms. Data from 60 women aged from 40 to 67 (mean 58.0; SD 6.97) with breast cancer diagnosis were analyzed. The participants completed three questionnaires: the Impact of Event Scale-Revised to assess PTSD symptoms, the Event Related Rumination Inventory to measure intrusive ...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: J Clin Psychol Med Settings Source Type: research
AbstractCognitive activity, manifested as trauma-related ruminative thinking, and deficits in emotional processing are believed to perpetuate the symptoms of posttraumatic stress disorder (PTSD). The aim of this study was to determine the mediating role of rumination in the relationship between emotional processing difficulties and PTSD symptoms. Data from 60 women aged from 40 to 67 (mean 58.0; SD 6.97) with breast cancer diagnosis were analyzed. The participants completed three questionnaires: the Impact of Event Scale-Revised to assess PTSD symptoms, the Event Related Rumination Inventory to measure intrusive and delibe...
Source: Journal of Clinical Psychology in Medical Settings - Category: Psychiatry & Psychology Source Type: research
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
Post-traumatic growth in cancer patients refers to perceived positive changes following cancer diagnosis and treatment. Little is known about the status and factors related to posttraumatic growth among Chinese patients with lung cancer. To investigate the status and factors of posttraumatic growth among Chinese patients with lung cancer. A cross-sectional design was adopted in this study. Patients (N = 173) from the oncology unit at one teaching hospital in Sichuan were recruited. Posttraumatic growth, depression, anxiety, and coping style were self-reported by the patients. Multiple linear regression analysis was to ex...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
CONCLUSIONS: Evidence shows efficacy of pregabalin in postherpetic neuralgia, painful diabetic neuralgia, and mixed or unclassified post-traumatic neuropathic pain, and absence of efficacy in HIV neuropathy; evidence of efficacy in central neuropathic pain is inadequate. Some people will derive substantial benefit with pregabalin; more will have moderate benefit, but many will have no benefit or will discontinue treatment. There were no substantial changes since the 2009 review. PMID: 30673120 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
OBJECTIVE To identify factors associated with psychosocial, physical and practical difficulties of daily living and distress among cancer survivors from a regional area in Australia. Design Cross-sectional study. Setting Riverina region of southern New Sou...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Abstract Breast cancer survivors report persistent psychological and physical symptoms, which affect their quality of life and may challenge the recovery process. Due to social, cultural, and linguistic barriers, culturally sensitive care is largely unavailable for Chinese Americans, and their psychological needs are not often addressed. We aimed to investigate whether the Joy Luck Academy (JLA), a psychosocial intervention providing both information and peer support, was associated with positive adjustment among Chinese American breast cancer survivors. Thirty-nine Chinese American breast cancer survivors partici...
Source: Behavioral Medicine - Category: Psychiatry Authors: Tags: Behav Med Source Type: research
ConclusionsOur findings highlight the important role of sub-ethnic cultural orientation in the efficacy of psychosocial interventions targeting immigrant populations.Trial RegistrationClinicalTrials.gov Identifier: NCT03546673
Source: International Journal of Behavioral Medicine - Category: Psychiatry Source Type: research
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