Effect of crotonaldehyde on the induction of COX-2 expression in human endothelial cells

In this study, we evaluated the effect of CRA stimulation on COX-2 expression in human umbilical vein endothelial cel ls. CRA-stimulated COX-2 induction was accompanied by enhanced p38 phosphorylation and PGE2 generation. However, CRA-induced PGE2 production was reduced by pretreatment with an inhibitor of p38 MAPK. These results demonstrated that in human endothelial cells, CRA-induced COX-2-dependent PGE2 generation was mediated by p38 MAPK, and CRA may play a role in the development of inflammation.
Source: Molecular and Cellular Toxicology - Category: Cytology Source Type: research