Ovulation Induction and Controlled Ovarian Stimulation Using Letrozole Gonadotropin Combination: A Single Center Retrospective Cohort Study
Conclusion(s) Letrozole-low dose gonadotropins combination appears to be effective across different causes of infertility for superovulation. The letrozole-low dose gonadotropin combination resulted in high rate of monofolliculogenesis, low occurrence of multiple gestations and no case of OHSS or cycle cancellation.
This study was conducted to understand the relationship of the mutations of some thrombophilia-associated gene polymorphism (heterozygous/homozygous) with RPL. We compared patients with 2 abortions to patients with 3 or more abortions among Turkish women. MATERIAL AND METHODS In this study, patients previously diagnosed with habitual abortus at Obstetrics and Gynecology outpatient clinics in Turkey between 2012 and 2016 were included. In their peripheral blood, we detected factor V Leiden H1299R, prothrombin G20210A, MTHFR C677T, MTHFR A1298C, PAI-1 4G/5G, and PAI-1 4G/4G gene mutations. RESULTS In this study, we have obse...
CONCLUSIONS Women with PCOS who underwent IVF, oral treatment with letrozole a day prior to treatment with hCG lowered E2 levels, but did not significantly reduce the incidence of OHSS. PMID: 29925074 [PubMed - in process]
Twink Allen has, without doubt, been one of the most influential and recognizable figures in the development of equine reproduction, and its establishment as a clinical specialty in its own right. For 50 years, he has been at the forefront of scientific discovery into reproductive endocrinology, embryo and placental development, and the development of novel clinical techniques and their refinement for clinical practice. Twink ’s academic endeavours extend into nearly all aspects of equine reproduction, including early embryo development, the developmental origins of adult health and disease (the ‘Barker’ ...
Synchronization between donor and recipient mares is an essential factor for pregnancy establishment in embryo transfer (ET) protocols. Several protocols using long acting progesterone (P4LA) have been used for the synchronization of recipient mares. However, these protocols do not allow reuse these mares in a short time after P4LA application. In this context, the efficiency of progesterone-releasing intravaginal device (DP4) on increase plasma progesterone (P4) levels and the quickly decrease on P4 levels after DP4 removal, showed an interesting results to use this to prepare equine recipients.
Endometrosis of equine endometrium comprises severe fibrosis and is mentioned as the main cause of the embryonic or fetal loss. Endometrosis is evidenced by morphologic and physiological alterations in the endometrium, and recently we have reported fibrosis to affect the secretory function of endometrium. However, the fibrosis effect on myometrium function is unclear. Contractions of myometrium and embryo movement during the early stage of pregnancy are mechanisms involved in the maternal recognition of pregnancy in mares.
Glucosinolates (GSL), which are commonly found in Brassicaceae family plants, may have negative effects on animal health. Major GSL metabolites such as isothiocyanates, thiocyanates and oxazolidinethione disrupt iodine availability to the thyroid, thus causing thyroid dysfunction. Maternal thyroid health and adequate levels of iodine are essential for normal fetal development, especially growth and maturation of the musculoskeletal system in the second and third trimester of gestation. Consumption of plants containing GSL during pregnancy has been linked to congenital hypothyroidism dysmaturity syndrome in foals (CHDS).
Mechanisms controlling development and function of equine corpus luteum (CL) may involve factors produced within and outside this gland. Progesterone (P4), a main hormone produced by CL, is necessary for pregnancy establishment and maintenance. In mares, gestation depends not only on the support of P4 but also on other luteotrophic factors such as prostaglandins (PGs). PGE2 a known luteotrophic factor, stimulates the P4 production by luteal steroidogenic cells in many species. Chorionic gonadotropin (CG) has luteinizing hormone-like activity, playing important roles in regulation of CL and endometrial functions.
Increasing age is inversely related to fertility in females of all species. AMH is secreted by the granulosa cells of growing follicles and plays an important role in the regulation of the early stages of follicular development . In women, AMH levels progressively decline with age, reflecting a decline in ‘growing’ follicle populations, with levels eventually being undetectable in menopausal women . Therefore, AMH levels are used to predict the age of onset of decreased fertility in women.
Endometritis is one of the main causes of fertility reduction in mares. It can cause several complications such as inability to become pregnant, early embryonic death, abortion, placentitis, neonatal septicemia and post-partum metritis (Troedsson MHT, 1999, Theriogenology, 52, 461-471). A correct diagnosis, together with characterization of degree and type of inflammation, is of extreme relevance and therapeutic protocol should be specific for each (Cadario M, 2014; The Practitioner, vol.1,pp. 21 –25).
The uterus is a dynamic physiological system in which cell proliferation and differentiation occur during pregnancy . A swift endometrial adaptation occurs when the embryo enters the uterus. Ciliated cell populations decrease progressively, and other histomorphometric endometrial changes occur from the 7th day after ovulation when compared to cyclic mares .