Testicular Cancer Increasing in Young Hispanic AmericansTesticular Cancer Increasing in Young Hispanic Americans

The incidence of testicular germ cell tumors has risen substantially in Hispanic adolescents and young adults in recent years in the United States. Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

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Publication date: Available online 19 June 2019Source: Biosensors and BioelectronicsAuthor(s): Sattar Akbari Nakhjavani, Hadi Afsharan, Balal Khalilzadeh, Mohammad Hossein Ghahremani, Sandro Carrara, Yadollah OmidiAbstractCarcinoembryonic antigen (CEA) is an important oncomarker for the detection of breast cancer. For ultra-sensitive sensing of CEA with great specificity and accuracy, an innovative and reliable electrochemical immunosensor was developed using various nano-hybrids. A glassy carbon electrode (GC) was modified with thiolated graphene oxide (T-GO) to elevate the active surface area of the electrode. The strept...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Publication date: Available online 19 June 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Diana C. Márquez-Garbán, Gang Deng, Begonya Comin-Anduix, Alejandro J. Garcia, Yanpeng Xing, Hsiao-Wang Chen, Gardenia Cheung-Lau, Nalo Hamilton, Michael E. Jung, Richard J. PietrasAbstractBreast cancers (BC) with expression of estrogen receptor-alpha (ERα) occur in more than 70% of newly-diagnosed patients in the U.S. Endocrine therapy with antiestrogens or aromatase inhibitors is an important intervention for BCs that express ERα, and it remains one of the most effective tar...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Publication date: 1 September 2019Source: Colloids and Surfaces B: Biointerfaces, Volume 181Author(s): Marina V. Novoselova, Denis V. Voronin, Tatiana O. Abakumova, Polina A. Demina, Arsenii V. Petrov, Vladimir V. Petrov, Timofei S. Zatsepin, Gleb B. Sukhorukov, Dmitry A. GorinAbstractHigh intensity focused ultrasound (HIFU) is widely used in medical practice, including cancer therapy. Also this approach is promising for remote release of encapsulated drugs in various other biomedical applications where local treatment is needed. Our approach underpins the minimization of HIFU impact on possible degradation of biological t...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: Available online 19 June 2019Source: Chemico-Biological InteractionsAuthor(s): Yeonhwa Song, I-Seul Park, Jiho Kim, Inhee Choi, Haeng Ran SeoAbstractLiver cancer is one of the most frequently occurring types of cancer with high mortality rate. Hepatocellular carcinoma (HCC) frequently metastasizes to lung, portal vein, and portal lymph nodes and most HCCs show strong resistance to conventional anticancer drugs. Cancer stem cells (CSCs) are considered to be responsible for resistance to therapies. Hence, recent advancements in the use of liver cancer stem cells (LCSCs) are rapidly gaining recognition as an...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: 1 November 2019Source: Chemical Engineering Journal, Volume 375Author(s): Huayan Yang, Yanmin Zhang, Jian Song, Meng Wang, Shaoning Yu, Liang Chen, Xiaomin Li, Shouning Yang, Lin YangAbstractThe integration of photothermal therapy (PTT) with photodynamic therapy (PDT) has great potential to revolutionize conventional therapeutic approaches for cancers. However, most of the currently developed nanoplatforms for combinatorial phototherapy require the participation of different components or activation of separate lasers. Therefore, a desirable photoactive agent with intrinsic single laser-activated combinat...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Human primordial germ cells (PGCs) have been described in the yolk sac wall around the beginning of the third week. From week 4 to 5, they migrate under control of SCF/c-KIT signaling pathway to the genital ridge, where they become gonocytes. PGCs and gonocytes express classic pluripotency markers, such as KIT, NANOG and OCT3/4 that, during spermatogonia differentiation, are gradually suppressed, and substituted by the expression of some germ cell specific genes, such as VASA, SOX17 and TSPY. These genes, during normal development of germ cells, are tightly regulated by epigenetic modification, in terms of microRNA express...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Authors: Facchini G, Rossetti S, Berretta M, Cavaliere C, D'Aniello C, Iovane G, Mollo G, Capasso M, Della Pepa C, Pesce L, Facchini S, Imbimbo C, Pisconti S Abstract OBJECTIVE: Testicular cancer is a relatively rare neoplasia, with an incidence of about 1,5% among male malignancies, usually in the third and fourth decade of life. Although several histological variants are known, with some histotypes affecting older patients (e.g., spermatocytic seminoma), there is a clear predominance (90-95%) of germ cell tumors among young adults patients1. Testicular Germ Cell Tumor (TGCT), undoubtedly the seminoma histological...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
AbstractGerm cell tumors (GCTs) are one of the most common tumors in adolescents and young adults. There is paucity of data on GCT from low –middle-income countries (LMIC). The present study was conducted to assess the demographic features, clinical manifestations, pathology, and outcomes of GCT patients treated at our center. Patients with testicular GCT above the age of 18 years, treated at our center from 2001 to 2015 were included in the study. Data were extracted retrospectively from the case records. Event-free survival (EFS) and overall survival (OS) were calculated using the Kaplan–Meier method and the ...
Source: Medical Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsSocioeconomic disparities continue to be barriers for young adults presenting with testicular cancer in the United States. Longer prospective follow-up will be required to assess the impact of payer status with the reportedly increased health coverage fostered by the ACA.
Source: Urology Practice - Category: Urology & Nephrology Source Type: research
UCLA researchers have made new inroads into understanding germ cell tumors, a diverse and rare group of cancers that begin in germ cells — the cells that develop into sperm and eggs. The researchers developed a protocol to recreate germ cell tumor cells from stem cells and used the new model to study the genetics of the cancer.Their findings could point the way toward new drugs to treat germ cell tumors, which account for around 3 percent of all cases of childhood and adolescent cancer.The study, published in Stem Cell Research, was led by Amander Clark, a UCLA professor of molecular cell and developmental biology an...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
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