Which factors influence the development of GVHD in HLA-matched or mismatched transplants?

Publication date: Available online 22 September 2017 Source:Best Practice & Research Clinical Haematology Author(s): Effie W. Petersdorf The sheer diversity of HLA alleles makes the probability of finding matched unrelated donors for patients requiring hematopoietic cell transplantation (HCT) a complex situation. New evidence suggests that mismatching at certain HLA loci may provide a greater benefit in terms of graft-versus-leukemia effect than other mismatches when HLA-matched donors are not available. This review summarizes the current understanding of HLA matching requirements for unrelated donor HCT.

Source: Best Practice and Research Clinical Haematology - September 23, 2017 Category: Hematology Source Type: research