It ’s not gonna’ kill you to take hormone replacement

It’s not going to kill you to take hormone replacement therapy. That’s the take home message from the latest analysis of the Women’s Health Initiative, the largest and longest randomized trial of hormone replacement therapy (HRT) in menopausal women. After almost 18 years of follow up in the WHI, there was no increase in overall mortality, including death rates from cancer, in women taking HRT for up to 5.6 years (estrogen plus progestin) or 7.2 years (estrogen alone). There was a non-significant reduction in mortality among those who started HRT between ages 50 and 59, the group most likely to be prescribed hormone therapy for menopausal symptoms. I’ve blogged before about the results and limitations of the WHI, which found, on balance, that the health risks of HRT (breast cancer, blood clots, stroke) about equaled its health benefits (protection against colon cancer and osteoporosis) in women staring HRT on average 10 years after the onset of menopause. The study (and the US Preventive Services Task Force) concluded that there was no reason for women to take HRT for preventive health reasons. The biggest criticism of the WHI was that it did not include women most likely to benefit from taking HRT – those with hot flashes, night sweats, insomnia and other menopausal symptoms. These women start HRT at menopause, not 10 years after it’s over. In this younger group, more recent research suggests there may be a reduction in heart dis...
Source: The Blog That Ate Manhattan - Category: Primary Care Authors: Tags: Hormone Replacement Menopause WHI breast cancer estrogen HRT Prempro Source Type: blogs

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Fifty years ago, in a golden moment of television comedy shows, Rowan &Martin’s Laugh-In program regularly featured “The Flying Fickle Finger of Fate” award.  Wikipedia says it “recognized actual dubious achievements by public individuals or institutions.” Do a Google search.  You’ll quickly see how popular this award became. Yes, I’m dating myself by going back 50 years.  But mine is the generation that often becomes obsessed with being given “the finger” by doctors for digital rectal exams (DRE) looking for prostate cancer. And it is in that context...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Mainstream media Oncology/Hematology Source Type: blogs
The updated American Heart Association (AHA)/American Stroke Association (ASA) Guidelines for the Early Management of Patients with Acute Ischemic Stroke were published in January 2018.1 The purpose of the guidelines is to provide an up-to-date, comprehensive set of recommendations for clinicians caring for adult patients with acute arterial ischemic stroke in a single document. The guidelines detail new and updated recommendations that reflect and incorporate the most recent literature in the evaluation and management of acute ischemic stroke. Some sections of the latest guidelines have sparked debate in the medical commu...
Source: Western Journal of Emergency Medicine - Category: Emergency Medicine Source Type: research
CONCLUSION: Combined treatment at extremely low concentration of two agents from natural products, As2O3 and resveratrol, has high potential as a cocktail of anticancer drugs for neuroblastoma. PMID: 30343279 [PubMed - in process]
Source: Genomics Proteomics ... - Category: Genetics & Stem Cells Authors: Tags: Cancer Genomics Proteomics Source Type: research
In this study, the ethanolic extracts prepared from fresh and dried leaves, bark, and seed skin of Pra (Elateriospermum tapos Blume.) were tested for their antioxidant activity using a ferric reducing ability of plasma (FRAP) assay. The antiproliferative activi...
Source: Journal of Medicinal Plants Research - Category: Complementary Medicine Source Type: research
While becoming pregnant is generally possible for younger breast cancer patients, researchers believe many women change their minds after treatment.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
Researchers tested whether 2 years of maintenance therapy with olaparib would improve outcomes in advanced ovarian cancer patients.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
Researchers tested whether immunotherapy could be safely used in HIV-positive patients with cancer.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
BOSTON (CBS) – Last week, Canada became the second country to legalize marijuana, but now Canadian scientists say more research is needed to know whether smoking pot is harmful to the lungs. While many tout the drug’s medicinal uses, some experts think those benefits have been overstated and that the potential harms have been understated. Marijuana is similar to tobacco except that it contains THC which causes the “high”. Some studies have suggested smoking the drug can cause respiratory symptoms and lung inflammation but what about long-term use? Can smoking marijuana cause lung cancer and chronic ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Healthwatch Dr. Mallika Marshall Marijuana Source Type: news
(MedPage Today) -- Stereotactic body radiation therapy demonstrates efficacy in longer follow-up study
Source: MedPage Today Hematology/Oncology - Category: Hematology Source Type: news
HOW TO SLEEP: The clocks go back an hour on Sunday which means an extra hour in bed in the morning. But daylight saving can disturb your sleep routine. A sleep expert recommends seven tips for getting a better night ’s sleep.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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