Isolation and structure elucidation of flavonoids from Amburana cearensis resin and identification of human DNA topoisomerase II- α inhibitors

In this study, we isolated 15 principal phenolics and established their structures by different spectroscopic methods, including 1D and 2D NMR experiments, as well HR-ESI–MS analysis. The isolated reference compounds were used to explore fragmentation pathways. Compound identification was based on the exact mass, general fragmentation behaviors, retention times and UV absorption. The activity of the principal compounds against human DNA topoisomerase II-α was evaluated. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research