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Epilepsy drug's safety reviewed over pregnancy risk

Women whose children have been harmed by sodium valproate will give evidence to a European panel.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news

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Higher doses of the drug taken early in pregnancy by women with epilepsy were associated with higher risk for oral clefts in offspring; lower doses used for other indications showed a weaker link.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news
(Natural News) In the last 10 years, topiramate, an anti-epileptic drug, has been increasingly prescribed to prevent seizures. It is also used to treat bipolar disorder and migraine headaches. Topiramate is also an ingredient for a weight-loss drug that was recently approved by the Food and Drug Administration (FDA). Earlier studies have determined that women who took topiramate...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Publication date: February 2018 Source:Epilepsy & Behavior, Volume 79 Author(s): Maryam Mahmoodkhani, Ehsan Saboory, Shiva Roshan-Milani, Negar Azizi, Mojtaba Karimipour, Yosef Rasmi, Zafar Gholinejad Many studies have found that stress during pregnancy is linked to an increased incidence of epileptic behaviors and reproductive disorders. However, few works have investigated the effect of pregestational stress on seizure susceptibility in the offspring. We investigated the effect of pregestational stress on epileptic behaviors in the offspring as well as fertility rate in dams. The male and female rats were randomly d...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Abstract Many studies have found that stress during pregnancy is linked to an increased incidence of epileptic behaviors and reproductive disorders. However, few works have investigated the effect of pregestational stress on seizure susceptibility in the offspring. We investigated the effect of pregestational stress on epileptic behaviors in the offspring as well as fertility rate in dams. The male and female rats were randomly divided into four groups to form a combination of control and stressed groups for each sex. The rats were subjected to predatory stress (exposed to a cat) twice per day for 50 (male) and 15...
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
Risk of cleft lip or cleft palate is greater if mother takes a higher dose of the drug Related items fromOnMedica Adverse pregnancy outcomes far more likely in epilepsy Study reveals mental cost of epilepsy in pregnancy Cannabis derivative cannabidiol reduces seizures in severe epilepsy disorder New guidelines on epilepsy in pregnancy Epilepsy drug linked to 4,000 birth defects in France
Source: OnMedica Latest News - Category: UK Health Source Type: news
Authors: Willems LM, Zöllner JP, Paule E, Schubert-Bast S, Rosenow F, Strzelczyk A Abstract INTRODUCTION: Eslicarbazepine acetate (ESL) is a third-generation antiepileptic drug (AED) approved for adjunctive treatment in adults, children, and adolescents with focal-onset seizures. Recently ESL was approved for initial monotherapy in adults. The intention of this article is to review current evidence for ESL and to summarise its pharmacological profile in comparison to other AEDs of the dibenzazepine group. Areas covered: We performed a systematic literature search in electronic databases (MEDLINE database, Coch...
Source: Expert Review of Clinical Pharmacology - Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research
Harvard Medical School researchers discovered that 12.3 children in every 1,000 are born with an oral cleft for mothers on high doses of topiramate, which is branded as Topamax.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
(Brigham and Women's Hospital) A new study by investigators from Brigham and Women's Hospital and the Harvard T.H. Chan School of Public Health suggest that using topiramate in early pregnancy, particularly at the high doses used for epilepsy, increases the risk of oral clefts. Their results are published in Neurology.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Researchers found that pregnant women with epilepsy who take the drug topiramate during their first trimester  may boost the risk that their child will be born with a cleft lip or cleft palate.
Source: WebMD Health - Category: Consumer Health News Source Type: news
WEDNESDAY, Dec. 27, 2017 -- A common anti-seizure drug may pose a birth defect problem for pregnant women, a new study warns. Researchers found that pregnant women with epilepsy who take the drug topiramate during their first trimester may boost...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
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