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Epilepsy drug's safety reviewed over pregnancy risk

Women whose children have been harmed by sodium valproate will give evidence to a European panel.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news

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Nurses at The Walton Centre NHS Foundation Trust have helped devise a short animation designed to aid women with epilepsy plan and prepare for pregnancy.
Source: Nursing Times - Category: Nursing Source Type: news
(Wiley) New research indicates that use of the epilepsy drug lamotrigine during pregnancy does not increase the risk of birth malformations or neurodevelopmental disorders.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
The UK Parliament is to hold a debate on the use of epilepsy drug valproate in pregnancy on 19 October 2017, after campaigners and MPs called for a discussion on the drug ’s risk.
Source: The Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
CONCLUSION: Maternal thyroid function during pregnancy, particularly hypothyroidism, is associated with behavioural and psychiatric disorders in children. Further studies are needed with a capacity to adjust for a fuller range of confounding factors. PMID: 28982961 [PubMed - in process]
Source: European Journal of Endocrinology - Category: Endocrinology Authors: Tags: Eur J Endocrinol Source Type: research
A 2-year-old girl, born after uneventful pregnancy from healthy nonconsanguineous parents, presented with failure to thrive, microcephaly, facial dysmorphism, strabismus, nystagmus, axial hypotonia, lower limb spasticity/hyperreflexia, dystonic movements, and no active postures. Since the first months of life, developmental delay without any motor skills acquisition, drug-resistant epilepsy, and progressive spasticity had emerged. Neuroimaging revealed pontocerebellar hypoplasia with the figure of 8 midbrain appearance (figure), a distinctive sign for PCH8 or AMPD2 deficiency.1,2 Sanger sequencing of the adenosine monophos...
Source: Neurology - Category: Neurology Authors: Tags: MRI, All Clinical Neurology, All Pediatric, All Genetics RESIDENT AND FELLOW SECTION Source Type: research
ConclusionsAccording to our experience, lamotrigine is generally safe for pregnancy use, associated with minimal short term complications with no long term effects on the outcome.
Source: British Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: DRUGS IN PREGNANCY AND LACTATION Source Type: research
An estimated 20,000 British children have been severely harmed because their mothers took the drug sodium valproate during pregnancy.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
PARIS (Reuters) - More than three decades after links emerged between Sanofi's epilepsy drug valproate and birth defects, many pregnant women remain unaware of the risks, patients, doctors and researchers said on Tuesday.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Warnings about the risk posed by taking the epilepsy drug sodium valproate during pregnancy are note reaching patients, a charity survey has indicated.
Source: Nursing Times - Category: Nursing Source Type: news
This study included singleton liveborn infants born to women enrolled in the North American Antiepileptic Drug Pregnancy Registry between 1997 and 2016. Data were collected prospectively through telephone interviews. The prevalence of preterm birth (
Source: Annals of Neurology - Category: Neurology Authors: Tags: Research Article Source Type: research
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