Repeating platinum/bevacizumab in recurrent or progressive cervical cancer yields marginal survival benefits

Publication date: Available online 20 September 2017 Source:Gynecologic Oncology Reports Author(s): Abigail S. Zamorano, Leping Wan, Matthew A. Powell, L. Stewart Massad Our objective was to assess overall survival of cervical cancer patients following prior platinum/bevacizumab chemotherapy, comparing retreatment with platinum/bevacizumab with alternative therapies. A retrospective analysis was performed of women who received platinum/bevacizumab (PB) chemotherapy for cervical cancer at Washington University between July 1, 2005 and December 31, 2015. Wilcoxon rank-sum exact test and Fisher's exact test were used to compare the treatment groups, and Kaplan Meier curves were generated. Cox regression analyses were performed, with treatment free interval and prior therapy response included as covariates. Of 84 patients who received PB chemotherapy, 59 (70%) received no second line chemotherapy, as they did not recur, progressed without further chemotherapy, were lost to follow up, or expired. Of the remaining 25 patients, 9 were retreated with the combination of platinum/bevacizumab (PB), 6 were retreated with a platinum regimen without bevacizumab (P), and 10 were retreated with neither (not-P). The only long-term survivor was in the not-P group and was treated with an immunotherapy agent. Median overall survival of all patients was 7.1months. There was a marginal difference in survival between women in the PB and not-PB groups (11.8 versus 5.7months; HR 3.02, 95% CI, 0...
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research