Toxicological evaluation of an aqueous suspension from leaves and stems of Petiveria alliacea L (Phytolaccaceae)

Conclusions P. alliacea powder from stems and leaves was classed in the hazard category 5 (LD50>2000 mg/kg) according to the acute toxicology study. There were no toxicity signs at 1000mg/kg in the repeated dose study, although higher values of total leukocytes were found in the satellite and males of the experimental group, which were attributed to the immunomodulatory properties of this plant. According to GC-MS, the prevailing compounds identified were phytol, (R)-(-)-(Z)−14-methyl-8-hexadecen-1-ol, 1-(2-hydrohyethyl)−1,2,4-triazole and methyl β-dimethylaminoisobutyrate. In conclusion, the oral administration of the P. alliacea powder to Sprague Dawley rats did not result in deaths and was not associated with adverse effects reflected in the general condition, body weights or histopathological abnormalities. Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research