NOACs Cut Bleeding vs Warfarin Following Acute VTE

Dr Goldhaber reviews a meta-analysis he coauthored of RE-COVER trial data suggesting that new oral anticoagulants may be a better option than warfarin for treating acute VTE.
Source: Medscape Critical Care Podcast - Category: Intensive Care Authors: Source Type: podcasts

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Uterine fibroids (leiomyoma) are benign monoclonal neoplasms of the myometrium and represent the most common tumors in women worldwide. Tumors occur in ∼77% of women overall and are clinically manifest in ∼25% by age 45 years. Although benign, these tumors are nonetheless associated with significant morbidity; they are the primary indication for hysterectomy, and a major source of gynecologic and reproductive dysfunction, ranging from profuse m enstrual bleeding and pelvic pain to infertility, recurrent miscarriage, and preterm labor.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
Publication date: Available online 29 May 2020Source: International Journal of Surgery Case ReportsAuthor(s): María José Gómez-Jurado, Anna Curell, Rocío Martín, Amador García Ruiz-de-Gordejuela, Manel Armengol Carrasco
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
CONCLUSIONS: Our study showed that each technique has specific features, so that each one offers advantages and disadvantages. Nevertheless, all of them ensure high en bloc resection rates, whereas no difference exists for R0 resection rate. TEO provides the possibility to remove low rectal large lesions as compared to ESD and FTRD. PMID: 32456395 [PubMed - as supplied by publisher]
Source: Minerva Chirurgica - Category: Surgery Tags: Minerva Chir Source Type: research
Abstract Newborn male circumcision is a common elective surgical procedure for the removal of foreskin covering the glans penis. The American Academy of Pediatrics, the American College of Obstetricians and Gynecologists, the Centers for Disease Control and Prevention, and the American Academy of Family Physicians recognize that there are health benefits of newborn male circumcision but do not universally recommend the procedure. Performing male circumcision during the neonatal period has several advantages, including a lower risk of complications, faster healing, and lower cost. The three most common techniques f...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
Medtronic is recalling its HeartWare HVAD pump outflow graft and outflow graft strain relief because of the risk of breaks and tears during the pre-implant pump assembly process. FDA has identified this as a Class I recall. The Dublin-based company said it has received 92 complaints. The recalled products according to FDA’s release are: HeartWare HVAD Pump Outflow Graft and Outflow Graft Strain Relief Model Numbers:HVAD Pump Outflow Graft: 1125 HVAD Pump Implant Kit: 1103 HVAD Implant Accessories Kit: 1153 Distribution Dates: March 1, 2018 to April 1, 2020   Medtronic said the use of the affe...
Source: MDDI - Category: Medical Devices Tags: Cardiovascular Regulatory and Compliance Source Type: news
Condition:   Peptic Ulcer Bleeding Intervention:   Device: heat probe or hemoclip Sponsors:   Changhua Christian Hospital;   Taipei Medical University Hospital;   Dalin Tzu Chi General Hospital Withdrawn
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Becattini C, Cimini LA Abstract INTRODUCTION: Anticoagulant treatment reduces recurrent venous thromboembolism (VTE) by about 90% after index pulmonary embolism. Whether anticoagulant treatment also reduces mortality in these patients remains to be defined. The main counterbalance for life long anticoagulation is the risk for anticoagulants-associated bleeding. AREAS COVERED: Literature search was performed in PubMed and Embase. We aimed to review the risk for recurrent VTE over time after discontinuation of anticoagulants and the risks for bleeding and for fatal bleeding over time during anticoagulant...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
Condition:   Peptic Ulcer Bleeding Intervention:   Device: heat probe or hemoclip Sponsors:   Changhua Christian Hospital;   Taipei Medical University Hospital;   Dalin Tzu Chi General Hospital Withdrawn
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSION: Up to 12 months of elagolix with add-back therapy provided sustained reduction in menstrual blood loss in women with uterine leiomyomas, with the addition of add-back therapy attenuating the hypoestrogenic effects of elagolix alone. No new or unexpected safety concerns were associated with an additional 6 months of elagolix with addback therapy. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, NCT02925494. FUNDING SOURCE: AbbVie Inc funded this study. PMID: 32459423 [PubMed - in process]
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
Abstract Patients with ventricular assist devices (VADs) and extracorporeal membrane oxygenation (ECMO) suffer from an increased risk for thromboembolic events as well as for hemorrhages. High shear stress in the mechanical device results in acquired von Willebrand syndrome (AVWS), characterized by a loss of high-molecular-weight multimers of von Willebrand factor (VWF) leading to an increased bleeding risk. Onset of AVWS occurs within hours, persists during the whole period of mechanical support, and subsides rapidly after explantation. Patients with the older HeartMate II exhibit more severe AVWS than those with...
Source: Hamostaseologie - Category: Hematology Authors: Tags: Hamostaseologie Source Type: research
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