[Correspondence] Timing of surgical antimicrobial prophylaxis

In The Lancet Infectious Diseases, Walter P Weber and colleagues1 found that early administration (approximately 30 –75 min before the scheduled incision) of surgical antimicrobial prophylaxis did not significantly reduce the risk of surgical site infection (SSI) compared with late administration (approximately 0–30 min before the scheduled incision). The authors tested cefuroxime, a commonly used cephalospor in with a short half-life, plus metronidazole in colorectal surgery, in patients older than 18 years who underwent inpatients general surgery procedures as well as orthopaedic trauma and vascular procedures at two hospitals in Switzerland from February, 2013, to August, 2015.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Correspondence Source Type: research