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Research provides clues to treat depression, autism and other neuropsychiatric disorders

(Florida Atlantic University) Alterations in a naturally occurring chemical in the brain called serotonin have been linked to a number of neuropsychiatric disorders including depression, anxiety and autism. A team of researchers is revealing critical insights into the mechanisms that can drive diminished serotonin signaling during development and in adulthood to provide new ways of treating several widespread neuropsychiatric disorders associated with perturbed serotonin signaling.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news

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Conclusions Our findings revealed the potential pathways through which child autism symptomatology may adversely affect parental mental health. Our findings also highlighted the importance of designing multipronged intervention programs for families raising children with ASD in order to improve relevant family processes and reduce parental affective symptoms.
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
Mpofu Parent carers of children with Autism Spectrum Disorder (ASD) often report increased levels of stress, depression, and anxiety. Unmet parent carer mental health needs pose a significant risk to the psychological, physical, and social well-being of the parents of the child affected by ASD and jeopardize the adaptive functioning of the family as well as the potential of the child affected by ASD. This systematic review identifies key qualities of interventions supporting the mental health of parent carers and proposes practitioner-parent carer support guidelines. A search of four databases (Medline, PubMed, PsycINF...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
ConclusionsThese results suggest thatARHGEF10 is a candidate risk gene for ASD and that theArhgef10 knockout model could be a tool for studying the mechanisms of neurotransmission in ASD.Trial registrationAnimal studies were approved by the Institutional Animal Care and Use Committee of National Taiwan University (IACUC 20150023). Registered 1 August 2015.
Source: Molecular Autism - Category: Molecular Biology Source Type: research
Happy Saturday, Psych Central readers! Do you think your brain works the same way as your friends’ brains? Why are college students flocking to a class aimed at making them feel happier? What does self-defeating humor do to your psychological well-being? We’re about to find out in this week’s Psychology Around the Net. Similar Neural Responses Predict Friendship: In simpler terms, your brain probably works in ways similar to your friends’ brains. Could it be that birds of a feather really do flock together? One study says so. The Mental Health and Loneliness Paradox: Whether it’s anxiety, dep...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain and Behavior College Depression Disorders Friends Happiness Mental Health and Wellness Psychology Around the Net Research Students Women's Issues brain gene activity College Students happy Isolation Jessica Porten Lon Source Type: blogs
Publication date: 2 March 2018 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 82 Author(s): Hsing-Chang Ni, Hsiang-Yuan Lin, Wen-Yih Isaac Tseng, Yen-Nan Chiu, Yu-Yu Wu, Wen-Che Tsai, Susan Shur-Fen Gau Although recent studies revealed impaired self-regulation (dysregulation) in autism spectrum disorder (ASD), neural correlates of dysregulation and its impacts on autistic neuroanatomy remain unclear. Voxel-based morphometry was applied on structural MRI images in 81 ASD and 61 typically developing (TD) boys aged 7–17years. Dysregulation was defined by the sum of T-scores of Attention, ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
Internalizing symptoms like anxiety and depression are common and impairing in autism spectrum disorder (ASD). Here, we test the hypothesis that aberrant functional connectivity between three brain networks [salience network (SN), default-mode network (DMN), and frontoparietal network (FPN)] plays a role in the pathophysiology of internalizing in ASD.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Archival Report Source Type: research
Abstract The anxiety and autism realms are each complicated and heterogeneous, and relationships between the two areas are especially complex. Network analysis offers a promising approach to the phenotypic complexities of typical and atypical human behavior. The Revised Children's Anxiety and Depression Scale (RCADS) was used to assess anxiety in 126 high-functioning 9-13 year-olds with ASDs. Network graphs of Autism Diagnostic Observation Schedule items and RCADS anxiety total score, social, generalized, panic and separation anxiety subscores consistently found the anxiety node (score) to be highly peripheral. Al...
Source: Journal of Autism and Developmental Disorders - Category: Psychiatry Authors: Tags: J Autism Dev Disord Source Type: research
Abstract There is increased mental-health adversity among individuals with autism spectrum disorder. At the same time, sexual and gender minority groups experience poorer mental-health when compared to heteronormative populations. Recent research suggests that autistic individuals report increased non-heterosexuality and gender-dysphoric traits. The current study aimed to investigate whether as membership of minority grouping becomes increasingly narrowed, mental health worsened. The present study compared the rates of depression, anxiety, and stress using the DASS-21 and Personal Well-Being using the personal wel...
Source: Journal of Autism and Developmental Disorders - Category: Psychiatry Authors: Tags: J Autism Dev Disord Source Type: research
AbstractResearch findings suggest that behavioral interventions are effective in improving educational outcomes and fostering skill development in people with autism spectrum disorder (ASD). However, high rates of comorbidity between ASD and other psychological disorders, including depression and anxiety, indicate that standard behavioral approaches are not adequately addressing issues related to mental health in this population. Research emerging since the publication of the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) is advancing our understanding of the nature of childhood stress a...
Source: Clinical Social Work Journal - Category: Psychiatry & Psychology Source Type: research
AbstractThough seemingly distinct and autonomous, emerging evidence suggests there is a bidirectional interaction between the intestinal microbiota and the brain. This crosstalk may play a substantial role in neurologic diseases, including anxiety, depression, autism, multiple sclerosis, Parkinson ’s disease, and, potentially, Alzheimer’s disease. Long hypothesized by Metchnikoff and others well over 100 years ago, investigations into the mind–microbe axis is now seeing a rapid resurgence of research. If specific pathways and mechanisms of interaction are understood, it could have broad therapeutic potent...
Source: Neurotherapeutics - Category: Neurology Source Type: research
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