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Faulty cell signaling derails cerebral cortex development, could it lead to autism?

(University of North Carolina Health Care) As the embryonic brain develops, a complex cascade of cellular events occur, starting with progenitors -- the originating cells that generate neurons and spur proper cortex development. If this cascade malfunctions then the brain can develop abnormally. Eva Anton's lab at UNC has shown how the deletion of the protein APC in progenitor leads to massive disruption of brain development and the Wnt protein pathway, which previously was linked to genes associated with autism.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Waiting more than four years is just as risky, according to the researchers from the CDC, who assessed hundreds of US babies with developmental disorders.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
By the time children with autism spectrum disorder (ASD) are approaching elementary school age, they are already exhibiting symptoms that typically lead to lifelong social difficulties. Among these symptoms: impaired communication and interaction, an inability to self-regulate and modulate emotions, very narrow and specific interests, and sensory processing difficulties that make it difficult for them...continue reading The post Tools for navigating the world at large appeared first on Counseling Today.
Source: Counseling Today - Category: Psychiatry & Psychology Authors: Tags: Counseling Today Cover Stories autism Children & Adolescents Source Type: research
Summary This review examined evidence of the association between maternal pre‐pregnancy overweight/obesity status and child neurodevelopmental outcomes. PubMed and PsycINFO databases were systematically searched for empirical studies published before April 2017 using keywords related to prenatal obesity and children's neurodevelopment. Of 1483 identified papers, 41 were included in the systematic review, and 32 articles representing 36 cohorts were included in the meta‐analysis. Findings indicated that compared with children of normal weight mothers, children whose mothers were overweight or obese prior to pregnancy we...
Source: Obesity Reviews - Category: Eating Disorders & Weight Management Authors: Tags: Pediatric Obesity Source Type: research
CONCLUSIONS: Study findings suggest that family and health system factors, together, influence parent disclosure of CHA used for children with ASD. Multifaceted intervention concurrently targeting the CHA-related knowledge, beliefs, and self-efficacy of parents whose children have been recently diagnosed with ASD, in addition to the CHA-related attitudes and knowledge of their healthcare providers may promote disclosure and shared treatment decision-making about the use of CHA. PMID: 29154066 [PubMed - in process]
Source: Complementary Therapies in Medicine - Category: Complementary Medicine Authors: Tags: Complement Ther Med Source Type: research
This article describes assessment and reviews common pediatric communication disorders.
Source: Pediatric Clinics of North America - Category: Pediatrics Authors: Source Type: research
This article describes the Coaching in Context (CinC) process, a family-driven, culturally responsive structure that facilitates family identification and achievement of goals. CinC focuses on modification of the demands of an activity with guidance from a health care professional who coaches the family to increase their participation in everyday activities. An interprofessional team is key in this process. Working as a team and communicating effectively across professions supports the health professional who serves as the coach. Effective interprofessional team collaboration is possible; health professions share values fo...
Source: Pediatric Clinics of North America - Category: Pediatrics Authors: Source Type: research
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Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
(Wiley) Investigators have found a link between the amount of time between pregnancies and autism spectrum disorder in children.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Publication date: Available online 21 November 2017 Source:Neuroscience & Biobehavioral Reviews Author(s): Shlomit Beker, John J. Foxe, Sophie Molholm Difficulty integrating inputs from different sensory sources is commonly reported in individuals with Autism Spectrum Disorder (ASD). Accumulating evidence consistently points to altered patterns of behavioral reactions and neural activity when individuals with ASD observe or act upon information arriving through multiple sensory systems. For example, impairments in the integration of seen and heard speech appear to be particularly acute, with obvious implications for i...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
AbstractBoth autism spectrum disorder (ASD) and schizophrenia are often characterized as disorders of white matter integrity. Multimodal investigations have reported elevated metabolic rates, cerebral perfusion and basal activity in various white matter regions in schizophrenia, but none of these functions has previously been studied in ASD. We used18fluorodeoxyglucose positron emission tomography to compare white matter metabolic rates in subjects with ASD (n = 25) to those with schizophrenia (n = 41) and healthy controls (n = 55) across a wide range of stereotaxically placed regi...
Source: Brain Imaging and Behavior - Category: Neurology Source Type: research
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