Faulty cell signaling derails cerebral cortex development, could it lead to autism?

(University of North Carolina Health Care) As the embryonic brain develops, a complex cascade of cellular events occur, starting with progenitors -- the originating cells that generate neurons and spur proper cortex development. If this cascade malfunctions then the brain can develop abnormally. Eva Anton's lab at UNC has shown how the deletion of the protein APC in progenitor leads to massive disruption of brain development and the Wnt protein pathway, which previously was linked to genes associated with autism.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Authors: Russo L, Craig F, Ruggiero M, Mancuso C, Galluzzi R, Lorenzo A, Fanizza I, Trabacca A Abstract INTRODUCTION: Recent evidence suggests that impairments in social cognition are associated to the cognitive abilities needed to take several viewpoints in perceptual situations and body awareness. The aim of the current study was to investigate Visual Perspective Taking (VPT) and Body awareness performance in a group of children with Autism Spectrum Disorders (ASD) compared with a group of children with Intellectual Disability (ID) and typically developing (TD) children. METHODS: Our groups were administered ...
Source: Cognitive Neuropsychiatry - Category: Psychiatry Tags: Cogn Neuropsychiatry Source Type: research
One year after researchers published work on a physiological test for autism, a follow-up study confirmed its accuracy in assessing whether a child is on the autism spectrum.
Source: PharmaManufacturing.com - Category: Pharmaceuticals Source Type: news
Jocelyn V. Hull, Lisa B. Dokovna, Zachary J. Jacokes, Carinna M. Torgerson, Andrei Irimia, John Darrell Van Horn, the GENDAAR Research Consortium
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Massachusetts Institute of Technology  and Harvard researchers conducted the largest ever investigation into genetic links between 25 brain disorders. They delved into the genomes of one million patients.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Source: Journal of Allied Health - Category: Universities & Medical Training Authors: Tags: Interprofessional Practice and Education Source Type: research
(NYU Langone Health / NYU School of Medicine) A broken shuttle protein may hinder learning in people with intellectual disability, schizophrenia, or autism.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
This study investigated associations between chronic caregiving stress and distributions of T cell phenotypes in a sample of high stress mothers of children with Autism Spectrum Disorder (caregivers; n=91) and low stress mothers of neurotypical children (controls; n=88). Immune markers assessed were naïve (CD45RA+CD62L+), central memory (CD45RA-CD62L+), and effector memory (CD45RA-CD62L-) CD4+ and CD8+ T cells. We also examined the ratio of effector to naïve (E:N) CD4+ and CD8+ T cells. In models adjusted for age, body mass index, race/ethnicity, and antidepressant use, caregivers displayed higher percentages of ...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Autism spectrum disorders (ASD) are neurodevelopmental disorders with continuous disturbance of cognitive flexibility and social communication, restricted, repetitive patterns of interests and behavior (O'Connor, 2012; Schelinski et al., 2016). Emerging evidence has been almost proving the idea that ASD is a condition of altered brain functional connectivity, especially in resting-state. Previous brain connectivity studies using functional magnetic resonance imaging (fMRI) in young adults with ASD showed reduction of resting-state connectivity at the medial prefrontal cortex (mPFC), the anterior hub of the default-mode net...
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Tags: Editorial Source Type: research
AbstractAutism spectrum disorder (ASD) is a neuro-behavioral syndrome with a broad spectrum of different mechanisms and etiologies that are caused by abnormal brain development. To date, no highly reliable and effective diagnostic biomarker to assess ASD is available so far. The present study investigated the predictivity potential of some suggested markers in ASD diagnosis focusing onto the relative ratios of several plasma biomarkers of electron transport chain function, and mitochondrial metabolism in 41 patients with ASD evaluated for behavior deficits measured using Childhood Autism Rating Scales (CARS). The control m...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
AbstractYoung children (n = 7526) assessed within a statewide early intervention program between 2008 and 2015 were screened for autism spectrum disorder (ASD) using the Baby and Infant Screen for Children with aUtIsm Traits- Part 1 (BISCUIT- Part 1). The relationship between premature birth, birth weight, and ASD scree ning outcome was examined using bivariate analyses and multivariate logistic regression analyses (adjusted for child’s gender, ethnicity, age at screening, and developmental delays). Results indicated that birth weight was a stronger predictor of screening outcome than premature birth, w...
Source: Journal of Developmental and Physical Disabilities - Category: Disability Source Type: research
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