Primary lung cancer in Assiut University Hospitals: Pattern of presentation within four years (January 2011: December 2014)

Conclusions Knowing that the incidence of lung cancer increased globally in both male and female, the relatively lower male to female ratio when compared with other studies, may reflect at least an increasing in the lung cancer rates among female. Smoking still remains the major risk factor in pathogenesis of primary lung cancer. COPD could be considered an important respiratory disorder that tied to bronchogenic carcinoma risk. Interestingly, the incidence of adenocarcinoma surpassed that of squamous cell carcinoma. Unfortunately, presentation of the patient at later stages of illness was common.
Source: Egyptian Journal of Chest Diseases and Tuberculosis - Category: Respiratory Medicine Source Type: research

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ConclusionsThese observations suggest that SYD is effective in the enhancement of antioxidant ability via activation of Nrf2 pathway and the up-regulation of Nrf2-downstream phase II enzymes expression. The anti-inflammation and antioxidant action of SYD together contributes to the prevention and treatment of ulcerrelated colorectal cancer.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
In this study, a novel vitamin E succinate-based formulation of Ir (VES-Ir) combined with nanoscaled characteristics and synergistic combination was constructed through esterification. The conjugation makes amphiphilic VES-Ir prodrug self-assemble into nanoparticles with a fine diameter (VES-Ir NPs, 75.4 nm) of spherical morphology. Furthermore, VES-Ir NPs with a 1:1 drug-to-drug ratio was demonstrated to possess respectable physiological stability within 72 h test, while can react to pH/esterase-sensitive drug release in lysosomes internalized into tumor cells, potentially highlighting their alleviating side effects. Comp...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 22 January 2020Source: International Journal of PharmaceuticsAuthor(s): Tao Tan, Yuqi Wang, Hong Wang, Haiqiang Cao, Zhiwan Wang, Jing Wang, Jie Li, Yaping Li, Zhiwen Zhang, Siling Wang
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Publication date: April 2020Source: Biomedicine &Pharmacotherapy, Volume 124Author(s): Danielle Kamato, Peter J. LittleAbstractThis review will cover the signalling pathways leading to the phosphorylation of the Smad linker region independent of Smad carboxy terminal phosphorylation. Characterising Smad linker region as a signalling pathway in its own right will encourage comprehensive signalling studies to provide solutions for successful discovery and exploitation of drug targets. The review describes Smad transcription factor signalling distinct from Transforming Growth Factor (TGF)-β signalling. Novel signalli...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
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Source: Expert Opinion on Drug Delivery - Category: Drugs & Pharmacology Authors: Source Type: research
Authors: Hou T, Fan Y, Dan W, Liu B, Wang Z, Zeng J, Li L Abstract Chaperone-mediated autophagy (CMA), a selective form of autophagy, where cellular proteins with KFERQ-like motif are targeted to the lysosome for degradation, is necessary to maintain cellular homeostasis. The role of CMA in neurodegenerative diseases has been extensively studied in the past decades, with defects in the pathway being strongly associated with disease. Recently, accumulating evidence has demonstrated a consistent increase in basal CMA activity in a wide array of cancer cell lines and human tumor biopsies, suggesting a potential link b...
Source: Histology and Histopathology - Category: Cytology Tags: Histol Histopathol Source Type: research
ConclusionsDentists, dental students, and laypersons decreased their ratings with increased inclination of the occlusal plane; however, laypersons still graded all the 2D and 3D images as esthetically pleasant, giving consistently higher ratings than the dentists and dental students. Overall, 3D simulations obtained higher ratings than 2D images, but the positive effect decreased for the student observers and decreased even further for laypersons.
Source: The Journal of Prosthetic Dentistry - Category: Dentistry Source Type: research
ConclusionsDespite the inherent bias of a retrospective analysis, our long-term results showed a low toxicity profile with a relatively low rate of biochemical control for HT re-treatment in patients affected by local radiorecurrent prostate cancer. Prospective trials are needed to investigate the role of EBRT in this setting.
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
Publication date: Available online 29 November 2019Source: Practical Radiation OncologyAuthor(s): Robert A. Scranton, Saeed Sadrameli, Edward Brian Butler, Andrew Farach, Hui-Chuan Wang, Bin S. Teh, Ivo W. Tremont-Lukats, Steve H. Fung, Paolo Zanotti-Fregonara, Robert C. RostomilyAbstractStereotactic radiosurgery (SRS) or radiotherapy (SRT) is commonly used to treat brain metastasis (BM). While effective in achieving tumor control, a significant number of BM patients exhibit lesion growth on follow-up MR imaging after SRS which cannot reliably distinguish between tumor growth, radiation necrosis (RN) or a mixture of both. ...
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 26 November 2019Source: Practical Radiation OncologyAuthor(s): Gabriela M. Alban, Daniela L. Buscariollo, Teresa Cheng, Jennifer Pretz, Betty Krechmer, Ivan Buzurovic, Lisa Singer, Martin King, Larissa LeeAbstractPurposeOur purpose was to evaluate outcomes and sites of failure for women with early stage endometrial adenocarcinoma treated with adjuvant high-dose-rate (HDR) vaginal brachytherapy (VB) with a low dose scheme.Methods and MaterialsRetrospective review identified 318 patients with International Federation of Gynecology and Obstetrics (FIGO) stage I-II endometrioid endometrial ca...
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
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