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A Methylome ‐Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder

In 671 mother–child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7–13) of oppositional defiant disorder (ODD), and the ODD subdimensions of irritable and headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity disorder (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome‐wide significant associations were identified for the ODD and headstrong, but not for irritable. Overlap analysis indicated biological correlates between ODD, headstrong, and ADHD. DNA methylation in ODD and headstrong was (to a degree) genetically influenced. DNA methylation associated with prenatal risk exposures of maternal anxiety (headstrong) and cigarette smoking (ODD and headstrong).
Source: Child Development - Category: Child Development Authors: Tags: Empirical Article Source Type: research

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1. To determine whether comorbid ADHD diagnosis (including subtype) predicts response to cognitive behavior therapy (CBT) for anxiety in children. 2. To examine change in ADHD symptoms after treatment of primary anxiety.
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Tags: New Research Source Type: research
If there’s one thing that you can be sure about, it’s that if you have kids they will throw tantrums. Emotions can be overwhelming at any age, and when young kids have big emotions they are unable to manage, their inability to process these emotions is often manifested in behavior such as tantrums, meltdowns and acting out. What is easily defined as misbehavior is often the manifestation of a child’s inability to deal with his or her emotions in an appropriate way. In other words, tantrums and meltdowns often mean that your child hasn’t yet learned to deal with emotions, and there is evidence to su...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Agitation Anger Brain and Behavior Bullying Children and Teens Parenting Psychology Research Students Anger Management Attention Deficit Hyperactivity Disorder Disruptive Mood Dysregulation Disorder Emotion Regulation Emotional D Source Type: blogs
Conclusions There are evidences of an important association between the two identified disorders, however without conclusive results on the interaction process. In order to establish therapeutic interventions and strategies to prevent the problem, it is necessary to advance research on the definition of the diagnostic criteria of ID, prevalence rates and predictors of the problem.
Source: Jornal Brasileiro de Psiquiatria - Category: Psychiatry Source Type: research
Publication date: Available online 12 May 2018 Source:Pharmacology & Therapeutics Author(s): Samata R. Sharma, Xenia Gonda, Frank I. Tarazi Autism Spectrum Disorder (ASD) refers to a group of neurodevelopmental disorders including autism, Asperger's syndrome (AS) and pervasive developmental disorder-not otherwise specified (PDD-NOS). The new diagnostic criteria of ASD focuses on two core domains: social communication impairment and restricted interests/repetitive behaviors. The prevalence of ASD has been steadily increasing over the past two decades, with current estimates reaching up to 1 in 36 children. Hereditary f...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
In this study, the United Kingdom (UK) arm (UK-LAMS) of the US National Institute of Mental Health (NIMH) supported Longitudinal Assessment of Manic Symptoms (LAMS) multi-site study was used to evaluate and retrospectively construct DMDD and MDEC diagnoses in order to compare them and understand the conditions they co-occur with, in order to improve the clinical understanding. In particular, the phenomenology of UK-LAMS participants (n = 117) was used to determine whether DMDD is a unique entity within the DSM-5. The findings showed that 24 of 68 participants with either DMDD or MDEC (35.3%) fulfilled both di...
Source: European Child and Adolescent Psychiatry - Category: Psychiatry Source Type: research
Conclusion: While the integrated, per capita, exposure of PM for a large fraction of the first-world may be less than 1 mg per day, links between several syndromes, including attention deficit hyperactivity disorder (ADHD), autism, loss of cognitive function, anxiety, asthma, chronic obstructive pulmonary disease (COPD), hypertension, stroke, and PM exposure have been suggested. This article reviews and summarizes such links reported in the literature.
Source: Journal of Occupational and Environmental Medicine - Category: Occupational Health Tags: Original Articles Source Type: research
Abstract Converging findings from recent research suggest a functional relationship between attention-deficit/hyperactivity disorder (ADHD)-related hyperactivity and demands on working memory (WM) in both children and adults. Excessive motor activity such as restlessness and fidgeting are not pathognomonic symptoms of ADHD, however, and are often associated with other diagnoses such as generalized anxiety disorder (GAD). Further, previous research indicates that anticipatory processing associated with anxiety can directly interfere with storage and rehearsal processes of WM. The topographical similarity of excessi...
Source: Behavior Therapy - Category: Psychiatry & Psychology Authors: Tags: Behav Ther Source Type: research
CONCLUSIONS: Maternal anxiety, depression and sleep disorders are associated with a relative increase in the number of ADHD-H, ADHD-I and total ADHD symptoms in preschoolers. PMID: 29665879 [PubMed - as supplied by publisher]
Source: Epidemiology and Psychiatric Sciences - Category: Psychiatry Tags: Epidemiol Psychiatr Sci Source Type: research
This study reviewed the current literature examining the potential relationship between use of antidepressants during pregnancy and attention-deficit/hyperactivity disorder (ADHD) in children. Methods PubMed was searched for English language reports between January 1, 1995, and July 31, 2017, by using combinations of the key words pregnancy, antidepressants, selective serotonin reuptake inhibitors (SSRIs), selective serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), children, offspring, and ADHD. Studies that reported association between ADHD in children and use of antidepressant in ...
Source: Journal of Clinical Psychopharmacology - Category: Psychiatry Tags: Review Article Source Type: research
Happy Saturday, sweet readers! Did everyone survive yesterday? Or did you even realize it was Friday 13th? Honestly, I didn’t remember until around noon yesterday. To quote the great Michael Scott, “I’m not superstitious, but I am a little stitious.” In other words, I didn’t wake up and begin anxiously awaiting doom around every corner, but, once I did remember what day it was…I kept an eye open. It’s only human nature. Anyway, let’s get on with everything this week’s Psychology Around the Net has to offer which includes science-backed ways to boost creativity, how to ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Alzheimer's Bipolar Celebrities Children and Teens College Creativity Disorders Happiness Phobia Psychology Around the Net Research Sleep Women's Issues Alzheimer's disease Bipolar Disorder brain Creative Thinking Embarra Source Type: blogs
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