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A Methylome ‐Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder

In 671 mother–child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7–13) of oppositional defiant disorder (ODD), and the ODD subdimensions of irritable and headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity disorder (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome‐wide significant associations were identified for the ODD and headstrong, but not for irritable. Overlap analysis indicated biological correlates between ODD, headstrong, and ADHD. DNA methylation in ODD and headstrong was (to a degree) genetically influenced. DNA methylation associated with prenatal risk exposures of maternal anxiety (headstrong) and cigarette smoking (ODD and headstrong).
Source: Child Development - Category: Child Development Authors: Tags: Empirical Article Source Type: research

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Publication date: January 2018 Source:Journal of Psychiatric Research, Volume 96 Author(s): Jianping Chen, Henrik Toft Sørensen, Maohua Miao, Hong Liang, Vera Ehrenstein, Ziliang Wang, Wei Yuan, Jiong Li Male congenital malformations as cryptorchidism may contribute to the development of neurodevelopmental disorders directly or via shared familial genetic and/or environmental factors, but the evidence is sparse. Using population-based health registries, we conducted a cohort study of all liveborn singleton boys in Denmark during 1979–2008. Boys with a diagnosis of cryptorchidism were categorized into the expo...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
ConclusionsThis is the first study demonstrating that Internet and face‐to‐face CBT for insomnia achieves long‐term reduction in adolescent psychopathology and does so by improving insomnia. This finding can have profound implications for youth mental health care.
Source: Journal of Child Psychology and Psychiatry - Category: Psychiatry Authors: Tags: Original Article Source Type: research
Abstract Purpose of review The pharmacological treatment of patients with epilepsy and psychiatric comorbidities may sometimes represent a therapeutic challenge. This review is focused on the pharmacological management of patients with epilepsy and psychiatric problems in terms of rationalization of the antiepileptic drug (AED) treatment and the pharmacological management of the most clinically relevant psychiatric comorbidities, namely mood and anxiety disorders, psychoses, and attention deficit hyperactivity disorder (ADHD). Recent findings Up to 8% of patients with drug-resistant epilepsy develop treatment-emer...
Source: Epilepsy Curr - Category: Neurology Authors: Tags: Curr Treat Options Neurol Source Type: research
AbstractPurpose of review The pharmacological treatment of patients with epilepsy and psychiatric comorbidities may sometimes represent a therapeutic challenge. This review is focused on the pharmacological management of patients with epilepsy and psychiatric problems in terms of rationalization of the antiepileptic drug (AED) treatment and the pharmacological management of the most clinically relevant psychiatric comorbidities, namely mood and anxiety disorders, psychoses, and attention deficit hyperactivity disorder (ADHD).Recent findings Up to 8% of patients with drug-resistant epilepsy develop treatment-emergent psychi...
Source: Current Treatment Options in Neurology - Category: Neurology Source Type: research
Abstract The current study examined the role negative self-statements have on the comorbidity between anxious symptomatology and ADHD-combined presentation (ADHD-C) and ADHD-predominantly inattentive (ADHD-I). A total of 114 children and adolescents with ADHD (M age = 10.15; SD = 2.30; range = 7-16) from a clinic-referred sample were grouped based on a semistructured diagnostic interview and consensus approach (ADHD-C, n = 62; ADHD-I, n = 52). Negative self-statements were measured using the Children's Automatic Thoughts Scale and the total score from the Multidimensional Anxiety Scale for Children was used to mea...
Source: Behavior Therapy - Category: Psychiatry & Psychology Authors: Tags: Behav Ther Source Type: research
ConclusionThis study did not show any beneficial effect of omega-3 supplement in children with mild ADHD symptoms.
Source: European Child and Adolescent Psychiatry - Category: Psychiatry Source Type: research
This study (1) examined whether boys or girls with ADHD differ in their sleep functioning, (2) evaluated comorbid symptoms as uniquely related to sleep functioning domains, and (3) explored whether sex moderated associations between comorbid symptoms and sleep. Participants were 181 children (ages 7 –13; 69% male; 82% White) diagnosed with ADHD. Parents completed measures assessing their child’s ADHD symptoms, comorbid symptoms, and sleep functioning. Girls had poorer sleep functioning than boys across most sleep functioning domains. Sixty percent of children met cutoff criteria for having sleep problems, thoug...
Source: European Child and Adolescent Psychiatry - Category: Psychiatry Source Type: research
CONCLUSION: Adults that screen positive for ADHD are at an increased risk for multimorbidity and several factors are important in this association. As many adults with ADHD remain undiagnosed, the results of this study highlight the importance of detecting adult ADHD as it may confer an increased risk for poorer health outcomes, including physical multimorbidity. PMID: 28957792 [PubMed - as supplied by publisher]
Source: Journal of the Association of European Psychiatrists - Category: Psychiatry Tags: Eur Psychiatry Source Type: research
This study examined symptoms of anxiety and depression among college students with attention-deficit/hyperactivity disorder (ADHD). PARTICIPANTS: Data were collected between March 2011 and March 2016 from 150 college students with ADHD and 150 c...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
CONCLUSIONS: Aberrant ventral striatum functional connectivity specifically predicts future risk for depressive disorder. This finding further emphasizes the need to understand how brain reward networks contribute to youth depression. PMID: 28946760 [PubMed - as supplied by publisher]
Source: The American Journal of Psychiatry - Category: Psychiatry Authors: Tags: Am J Psychiatry Source Type: research
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