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A Methylome ‐Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder

In 671 mother–child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7–13) of oppositional defiant disorder (ODD), and the ODD subdimensions of irritable and headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity disorder (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome‐wide significant associations were identified for the ODD and headstrong, but not for irritable. Overlap analysis indicated biological correlates between ODD, headstrong, and ADHD. DNA methylation in ODD and headstrong was (to a degree) genetically influenced. DNA methylation associated with prenatal risk exposures of maternal anxiety (headstrong) and cigarette smoking (ODD and headstrong).
Source: Child Development - Category: Child Development Authors: Tags: Empirical Article Source Type: research

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Conclusions: Attention deficit hyperactivity disorder is common in primary school children in Jeddah, and is associated with widespread psychiatric, academic, and behavioral problems, especially in boys. These findings have implications for the diagnosis and treatment of this serious neurobehavioral disorder. PMID: 29332109 [PubMed - in process]
Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
CONCLUSIONS: Results provide moderate support for the predictive validity of psychiatric disorders in preschoolers. Psychopathology in preschool is a significant risk factor for future psychiatric disorders during middle childhood and early adolescence. PMID: 29335030 [PubMed - as supplied by publisher]
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
Conclusions: Our results are consistent with the role ofDAT1 in the neurobiology of drug addiction. Nevertheless, the study of other genes, environmental factors, and their interactions is also important to gain a broader understanding of this condition.Neuropsychobiology 2017;75:141 –144
Source: Neuropsychobiology - Category: Psychiatry & Psychology Source Type: research
Publication date: February 2018 Source:Brain, Behavior, and Immunity, Volume 68 Author(s): Vanessa Coelho-Santos, Filipa L. Cardoso, Ricardo A. Leitão, Carlos A. Fontes-Ribeiro, Ana Paula Silva Attention deficit hyperactivity disorder (ADHD) is the most prevalent childhood mental disorders that often persists into adulthood. Moreover, methylphenidate (MPH) is the mainstay of medical treatment for this disorder. Yet, not much is known about the neurobiological impact of MPH on control versus ADHD conditions, which is crucial to simultaneously clarify the misuse/abuse versus therapeutic use of this psychostimulant. I...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Follow me on Twitter @drClaire Attention deficit hyperactivity disorder, or ADHD, is very common — according to the most recent statistics, one in 10 children between the ages of 4 and 17 has been diagnosed with this problem. So it’s not surprising that when parents notice that their child has trouble concentrating, is more active or impulsive than other children, and is having trouble in school, they think that their child might have ADHD. But ADHD isn’t the only problem that can cause a child to have trouble with concentration, behavior, or school performance. There are actually lots of problems that ca...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Behavioral Health Children's Health Mental Health Parenting Source Type: blogs
Significant advances have been made in the application of pharmacogenomic testing for the treatment of patients with psychiatric disorders. Over the past decade, a number of studies have evaluated the utility of pharmacogenomic testing in pediatric patients with psychiatric disorders. The evidence base for pharmacogenomic testing in youth with depressive and anxiety disorders as well as attention/deficit hyperactivity disorder (ADHD) is reviewed in this article. General pharmacogenomic principles are summarized and functional polymorphisms in P450 enzymes (and associated metabolizer phenotypes), the serotonin transporter p...
Source: Current Problems in Pediatric and Adolescent Health Care - Category: Pediatrics Authors: Source Type: research
Alterations in circulating thyroid hormone concentrations are associated with several psychological and behavioral disorders. In humans, behavioral disorders such as anxiety, depression, and attention-deficit hyperactivity disorder can be associated with t...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Violence and Weapons Issues Source Type: news
ABSTRACT:Objective:The present study compared sleep sufficiency in youth with current Tourette's disorder (TD), history of TD and matched case controls, and examined predictors of sufficient sleep using a large US population–based survey.Method:Participants were 673 caregivers of youth aged 6 to 17 years (298 with current TD, 122 with a history of TD with no endorsement of current diagnosis, and 254 matched case controls) from the 2007 and 2011–2012 versions of the National Survey of Children's Health. History and current TD status, current comorbidity (attention deficit/hyperactivity disorder, anxiety, and dep...
Source: Journal of Developmental and Behavioral Pediatrics - Category: Child Development Tags: Brief Reports Source Type: research
This study supports the hypothesis that altered thyroid signaling and aggressive behavior are linked. PMID: 29289659 [PubMed - as supplied by publisher]
Source: Hormones and Behavior - Category: Endocrinology Authors: Tags: Horm Behav Source Type: research
ConclusionsThis is the first randomised controlled trial to provide preliminary evidence of efficacy and acceptability of individual formulation‐based CBT for ADHD when added to TAU over TAU alone. This approach now needs to be tested in a larger multicentred randomised controlled trial.
Source: Acta Psychiatrica Scandinavica - Category: Psychiatry Authors: Tags: Original Article Source Type: research
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