Pneumocystis jirovecii genotyping: experience in a tertiary-care hospital in Northern Italy.

Pneumocystis jirovecii genotyping: experience in a tertiary-care hospital in Northern Italy. New Microbiol. 2017 Jul;40(3):208-211 Authors: Pini P, Orsi CF, La Regina A, Peppoloni S, Berrilli F, Blasi E, Di Cave D Abstract Respiratory samples from Pneumocystis jirovecii pneumonia (PJP) cases collected at a tertiary-care university hospital in Modena were analyzed for the presence of specific polymorphisms in the mitochondrial large subunit ribosomal RNA (mtLSU-rRNA). Retrospectively, 57 cases were selected in a six-year period and 34 out of the 57 processed BAL samples returned PCR positive results, thus allowing further molecular analysis. The following P.jirovecii genotype distribution was observed: genotype 3 (50%), genotype 2 (23%), genotype 1 (18%), genotypes 1 or 4 (9%). These data add novel insights on P.jirovecii epidemiology, investigating a previously unstudied area of Northern Italy. A peculiar local distribution is highlighted with respect to other areas within the national panorama, thus encouraging further in-depth studies in an attempt to better understand the overall situation concerning P.jirovecii genotype circulation. PMID: 28920631 [PubMed - in process]
Source: New Microbiologica - Category: Microbiology Tags: New Microbiol Source Type: research