Ca(II), Sr(II) and Ba(II) ion interaction with the rheumatoid arthritis drug tenoxicam: Structural, thermal, and biological characterization

In this study, the complexation properties of the drug Tenox with Ca(II), Sr(II) and Ba(II) ions in a (dichloromethane + water) binary solvent system are reported. The formed metal complexes were characterized structurally, thermally, and biologically. Tenox was found to act as a chelate monoanionic ligand towards all metal ions with complexation stoichiometry of 1:2 (Metal: Tenox) for Ca(II) and Sr(II) ions, and 1:1 for Ba(II) ions. The Tenox ligand behaves as a bidentate ligand when coordinated with Sr(II) or Ba(II) ions and as a tridentate ligand when coordinated with Ca(II) ions. The Sr(II) and Ba(II) complex of the Tenox ligand exhibited marked inhibitory effect on the cell growth of the C. albicans species. The free drug tenoxicam (Tenox) had no inhibitory activity towards the fungal strain Candida albicans. The complex of Tenox with Sr(II) ion exhibited marked inhibitory effect on the cell growth of this strain. The potency of the Sr(II)‐Tenox complex is 16% greater than that of the standard drug Amphotericin B against this fungal strain.
Source: Applied Organometallic Chemistry - Category: Chemistry Authors: Tags: FULL PAPER Source Type: research