8th Advances Against Aspergillosis: abstract submissions deadline

8th Advances Against Aspergillosis: abstract submissions deadlineDate: Wednesday, September 20, 2017Year: 2018Location: Lisbon, Portugal.Content-type: current_conferences
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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In this study, we investigated the role of Aspergillus proteases—which contribute to the pathogenesis of Aspergillus-induced diseases such as allergic bronchopulmonary aspergillosis, hypersensitivity pneumonitis, and atopic asthma—and their mechanisms of action in airway inflammation using primary human bronchial epithelial cells, and evaluated the inflammatory responses mediated by mitochondrial ROS. We found that Aspergillus proteases regulated the expression of multifunctional inflammatory cytokines such as interleukin (IL)−1β, −6, and −8, and transforming growth factor (TGF)-β, w...
Source: Redox Biology - Category: Biology Source Type: research
Publication date: March 2018Source: Journal de Mycologie Médicale, Volume 28, Issue 1Author(s): M.-P. Ledoux, J. Denis, Y. Nivoix, R. HerbrechtAbstractIsavuconazole, the active moiety of its prodrug isavuconazonium, is a new extended-spectrum triazole whose activity against yeasts, molds, including Aspergillus and mucorales, and dimorphic fungi has been shown in vitro and in preclinical models. The most relevant pharmacokinetics features are water-solubility of the prodrug, rapid cleavage of the prodrug into active moiety and cleavage product by plasmatic esterases, high oral bioavailability of isavuconazole with an...
Source: Journal of Medical Mycology - Category: Biology Source Type: research
Publication date: March 2018Source: Journal de Mycologie Médicale, Volume 28, Issue 1Author(s): J. Denis, M.-P. Ledoux, Y. Nivoix, R. HerbrechtAbstractTriazoles compounds are first-line agents for the treatment of invasive fungal diseases. Isavuconazole is the most recent triazole compound, approved in 2015 by the FDA and the EMA to treat invasive aspergillosis and mucormycosis. We reviewed here the in vitro activity of isavuconazole against a vast spectrum of species. Isavuconazole MICs were evaluated using CLSI, EUCAST or Etest methods, with no significant differences between the technics. Low MIC50 and MIC90 (
Source: Journal of Medical Mycology - Category: Biology Source Type: research
Publication date: September 2018Source: Medical Mycology Case Reports, Volume 21Author(s): Jessica D. Workum, Suzanne W. de Jong, Mark S. Gresnigt, Katharina L. Becker, Peter Pickkers, Frank L. van de Veerdonk, Yvonne F. Heijdra, Eva KolwijckAbstractInvasive pulmonary aspergillosis is increasingly described in non-neutropenic patients, such as patients with COPD receiving corticosteroids and the critically ill. Here, we present a case of a lethal pulmonary Aspergillus niger infection in a COPD patient. Immunological tests showed an impaired innate and adaptive immune response to Aspergillus. A history of COPD, unresponsive...
Source: Medical Mycology Case Reports - Category: Biology Source Type: research
Publication date: June 2018Source: Medical Mycology Case Reports, Volume 20Author(s): Yuuki Ohara, Takahiko Ito, Makoto Ito, Kyoko Yamashita, Shinya ToyokuniAbstractA 62-year-old previously healthy male who was a welder/smoker/drinker was admitted to Kani Tono Hospital for severe hypoxemia (Day 0). Initial physical and radiological examinations suggested an acute exacerbation of chronic obstructive pulmonary disease. However, respiratory failure developed rapidly, and he died on Day + 4. Aspergillus fumigatus was identified after his death, and he was diagnosed with invasive pulmonary aspergillosis. The clinical and path...
Source: Medical Mycology Case Reports - Category: Biology Source Type: research
ConclusionThis study demonstrated that A. tubingensis can cause skin infection; this constitutes the first report of a case of aspergillosis caused by A. tubingensis in Mexico.
Source: Journal of Medical Mycology - Category: Biology Source Type: research
We present a case of a patient with known Crohn's disease who developed invasive pulmonary aspergillosis. His clinical picture was further complicated by an uncommon immune response characterized by the development of granulomas encasing the Aspergillus forms found on his lung biopsy, likely representing a maladaptive response, possibly related to the effects of his granulomatous disease in the lungs. He was successfully treated with antifungal therapy and video assisted thoracoscopic surgery with placement of thoracostomy tube drainage for a parapneumonic effusion. We will discuss the factors leading to his atypical prese...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
ConclusionsIsolation of NTM or Aspergillus species from lung transplant recipients is uncommon. Adequate pre-transplant control and post-transplant management of NTM and Aspergillus infections allows for safe lung transplantation.
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
ConclusionCNS aspergillus infection in immunocompetent patients has distinct imaging features as compared to CNS aspergillosis in immunocompromised patients. A high index of suspicion in proper clinical settings, even with immunocompetent status and typical imaging features allow us to diagnose CNS aspergillosis in such patients.
Source: Journal of Neuroradiology - Category: Radiology Source Type: research
Publication date: May 2018Source: The Journal of Molecular Diagnostics, Volume 20, Issue 3Author(s): Julie Denis, Faezeh Forouzanfar, Raoul Herbrecht, Elise Toussaint, Romain Kessler, Marcela Sabou, Ermanno Candolfi, Valérie Letsher-BruInvasive pulmonary aspergillosis (IPA) is a common complication of immunosuppression. Rapid diagnosis using molecular techniques is essential to improve patient survival. PCR techniques are promising in enhancing Aspergillus detection in blood and respiratory samples. We evaluate for the first time the performances of two commercial real-time PCR kits, the A. fumigatus Bio-Evolution a...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
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