Approach to Diagnosis of Secondary Cardiomyopathies With Left Ventricular Hypertrophy

Left ventricular hypertrophy (LVH) is often encountered cardiac disorder with heterogeneous clinical presentation and course. Although unexplained LVH is the hallmark of hypertrophic cardiomyopathy, differential diagnosis of secondary cardiomyopathies with LVH has been needed. Because, disease-oriented treatments have made progress. For example, the enzyme replacement therapy for Anderson-Fabry disease promises the modification of natural course of disease. In the first half of this presentation, we will overview the clinical significance of diagnostic procedures such as medical history, physical examination, laboratory data, electrocardiography, echocardiography, cardiac magnetic resonance, and cardiac catheterization including endomyocardial biopsy, in secondary cardiomyopathies with LVH.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Source Type: research

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AbstractCurrent echocardiography techniques have allowed more precise assessment of cardiac structure and function of the several types of cardiomyopathies. Parameters derived from echocardiographic tissue imaging (ETI) —tissue Doppler, strain, strain rate, and others—are extensively used to provide a framework in the evaluation and management of cardiomyopathies. Generally, myocardial function assessed by ETI is depressed in all types of cardiomyopathies, non-ischemic dilated cardiomyopathy (DCM) in particular . In hypertrophic cardiomyopathy (HCM), ETI is useful to identify subclinical disease in family membe...
Source: Heart Failure Reviews - Category: Cardiology Source Type: research
Publication date: Available online 14 January 2020Source: European Journal of RadiologyAuthor(s): Zixian Chen, Chen Cui, Gang Yin, Yong Jiang, Weichun Wu, Junqiang Lei, Shunlin Guo, Zheng Zhang, Sirajuddin Arlene, Andrew E. Arai, Shihua Zhao, Minjie LuAbstractPurposeTo investigate the incidence, mechanism, and risk factors of aortic regurgitation (AR) in patients with hypertrophic cardiomyopathy (HCM) by using echocardiography and cardiac magnetic resonance (CMR).Methods105 HCM patients, 52 hypertension (HTN) patients and 50 healthy controls (HC) were retrospectively recruited. HCM patients were divided into 38 with AR (HC...
Source: European Journal of Radiology - Category: Radiology Source Type: research
HYPERTROPHIC CARDIOMYOPATHY (HCM) is a relatively common inherited cardiac disease characterized by asymmetrical left ventricle (LV) wall thickening. Because left ventricular outflow tract (LVOT) obstruction occurs in HCM and can lead to catastrophic circulatory collapse, its prevention is one of the most important issues in perioperative circulatory management. LVOT obstruction is induced or aggravated by a decrease in the preload or afterload; an increase in cardiac contractility or heart rate; or any combination of these factors.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Case Report Source Type: research
No abstract available
Source: Journal of Cardiovascular Medicine - Category: Cardiology Tags: Images in cardiovascular medicine Source Type: research
No abstract available
Source: Journal of Cardiovascular Medicine - Category: Cardiology Tags: Images in cardiovascular medicine Source Type: research
AbstractHyperuricemia has been regarded as a risk factor for various cardiovascular diseases. However, few studies have evaluated its influence on thromboembolism in hypertrophic cardiomyopathy (HCM) patients. The purpose of the present study is to investigate the association between hyperuricemia and thromboembolism in a retrospective HCM cohort. A total of 447 adult HCM patients were enrolled in this study from December 2008 to May 2016. Uric acid levels were measured at baseline. Hyperuricemia was defined as blood uric acid level>  360 µmol/L for female patients and>  420 µmol/L...
Source: Internal and Emergency Medicine - Category: Emergency Medicine Source Type: research
We examined frequency, clinical characteristics and AF‐related management and outcomes amongst this patient population.MethodsWe retrospectively studied consecutive probands with inherited cardiomyopathy (n=962) and inherited arrhythmia syndromes (n=195) evaluated between 2002 ‐2018.ResultsAF was observed in 5 ‐31% of patients, with the highest frequency in HCM. Age of AF onset was 45.8 ± 21.9 years in the inherited arrhythmia syndromes compared to 53.3 ± 15.3 years in the inherited cardiomyopathies, with 4 CPVT patients developing AF at median age of 20 years. Overall, 11% of patients with AF had a t r...
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionsCA was successful in restoring long ‐term sinus rhythm and improving symptomatic status in most HCM patients with refractory AF especially for those patients with small atrial size and mild symptoms. In addition, CA may contribute to the prevention of major clinical adverse events in the long‐term clinical course.This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Patients with hypertrophic cardiomyopathy (HCM) exhibit a variable phenotype with ventricular hypertrophy as the cardinal manifestation and left ventricular (LV) outflow tract obstruction (LVOTO) as a key pathophysiologic determinant. Patients with severe LVOTO usually present with exertional dyspnea, exertional syncope, and heart failure symptoms, while successful relief of LVOTO by pharmacological or invasive interventions leads to a dramatic improvement in clinical status. Proper management of obstructive HCM remains challenging and poses numerous clinical dilemmas.
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Conditions:   Cardiomyopathy, Dilated;   Cardiomyopathy, Hypertrophic;   Insulin Resistance Intervention:   Diagnostic Test: Oral glucose tolerance test Sponsor:   Le Bonheur Children's Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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