The Framework of Circulatory Equilibrium Can Predict the Quantitative Impact of Interatrial Shunt for Left Heart Failure on Hemodynamics

Background: Interatrial shunting (IAS) have been reported to lower left atrial pressure (LAP) in heart failure (HF). However, its quantitative impact on hemodynamics has not been explored. We predicted the impact of IAS on hemodynamics by the framework of circulatory equilibrium. Method: In 4 mongrel dogs, we connected the left and right atrium with centrifugal pump to create IAS and measured hemodynamics. We ligated left coronary arteries to create LHF. We predicted hemodynamic variables from the framework of circulatory equilibrium (Fig.  1) and compared with those measured.

Source: Journal of Cardiac Failure - September 20, 2017 Category: Cardiology Authors: Takuya Nishikawa, Keita Saku, Kiyoshi Uike, Genya Sunagawa, Takeshi Tohyama, Takuya Kishi, Kazunori Uemura, Kenji Sunagawa, Hiroyuki Tsutsui Source Type: research