Direct Contribution of Anemia to Cardiac Overload Determined by Natriuretic Peptide and Covariance Structure Analyses

Background: While anemia can occur concomitantly with chronic kidney disease (CKD), the adverse cardiovascular effects of anemia, including heart failure (HF), remain unclear. Thus, the direct effects of anemia on the left ventricular ejection fraction (LVEF), as a marker of systolic function, and the plasma B-type natriuretic peptide (BNP) level, as a marker of cardiac overload, were investigated. Methods: Covariance structure analyses were proposed for 1536 inpatients to examine the interactions among the estimated glomerular filtration rate, hemoglobin (Hb), LVEF, and LogBNP.

Source: Journal of Cardiac Failure - September 20, 2017 Category: Cardiology Authors: Mitsutoshi Tominaga, Yasunori Inoue, Makoto Kawai, Michihiro Yoshimura Source Type: research