Serum Micro-ribonucleic Acid-126 and -223 as a New Generation Biomarker for Cardiac Sarcoidosis

Background: Cardiac sarcoidosis is associated with poor prognosis. Clinical manifestations of cardiac sarcoidosis are non-specific, and the sensitivity and specificity of diagnostic modalities are limited. Serum micro RNAs (miRNAs) has been recently reported as a new generation biomarkers for various diseases such as cancer, neurological diseases, and immune diseases. To date, little is known whether serum miRNAs could be useful as diagnostic biomarkers for cardiac sarcoidosis. Methods: We first performed a genome-wide expression profiling for a total of 389 miRNAs (Human-miRNA ver.20) using peripheral blood samples of 5 patients with cardiac sarcoidosis (61  ± 9 years) and 3 healthy controls (54 ± 7 years).

Source: Journal of Cardiac Failure - September 20, 2017 Category: Cardiology Authors: Wakata Fujiwara, Ryo Yamada, Tomoya Ishiguro, Satoshi Okumura, Masataka Yoshinaga, Yoshinori Sugishita, Mutsuharu Hayashi, Yasuchika Kato, Yukio Ozaki, Hideo Izawa Source Type: research