Current mouse models of oral squamous cell carcinoma: Genetic and chemically induced models

Ninety percent of head and neck cancers are squamous cell carcinomas involving mucosal surfaces of the oral cavity, pharynx, and larynx. This cancer can affect any site in the oral mucosa, typically the tongue and floor of the mouth [1]. Oral squamous cell carcinoma (OSCC), a subset of head and neck squamous cell carcinoma, is one of the most common human malignancies worldwide [2,3]. Further, OSCC is the most common malignant tumor of the head and neck, and its incidence has increased in recent years [4].

Source: Oral Oncology - August 3, 2017 Category: Cancer & Oncology Authors: Kazuhisa Ishida, Hiroyuki Tomita, Takayuki Nakashima, Akihiro Hirata, Takauji Tanaka, Toshiyuki Shibata, Akira Hara Tags: Review Source Type: research