Mesothelioma Clinical Trials Involve Gene Therapy

Treatment options for malignant mesothelioma may soon include customized gene therapy, according to thoracic surgeon and scientist Dr. Prasad Adusumilli at Memorial Sloan Kettering Cancer Center in New York. Gene therapy involves a laboratory reprogramming of a patient’s own T cells, which are a type of white blood cell, to recognize and destroy the cancer. The U.S. Food and Drug Administration (FDA) recently approved the first gene therapy specifically for pediatric leukemia, signaling the start of a new approach to cancer treatment in this country. The newly approved treatment is also known as chimeric antigen receptor (CAR) T cell therapy, which includes removing T cells from a patient, arming them with a protein linked to a particular cancer and then returning those cells to the patient. CAR T cell therapy already has shown considerable promise with blood cancers such as leukemia, which prompted the FDA’s groundbreaking approval. But its effectiveness with solid tumors, such as mesothelioma, has been limited until recently. Memorial Sloan Kettering Leading the Way Memorial Sloan Kettering has been a worldwide leader in developing CAR T cell therapy for cancer, making it safer and more effective. Adusumilli, who specializes in thoracic cancers, is the chief investigator of a promising clinical trial involving T cells genetically engineered to target mesothelin, a protein found in almost 90 percent of pleural mesothelioma tumors. Early trial results are encourag...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: CAR T cell therapy checkpoint blockade chimeric antigen receptor T cell therapy Dr. Andy Haas Dr. Prasad Adusumilli Dr. Scott Gottlieb FDA Commissioner gene therapy cancer gene therapy for mesothelioma immunotherapy clinical trial mali Source Type: news

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Source: Expert Review of Medical Devices - Category: Medical Devices Tags: Expert Rev Med Devices Source Type: research
Chem. Commun., 2019, Advance Article DOI: 10.1039/C9CC01506J, CommunicationYuan Ma, Quanbing Mou, Lijuan Zhu, Yue Su, Xin Jin, Jing Feng, Deyue Yan, Xinyuan Zhu, Chuan Zhang Polygemcitabine nanogels assembled from DNA-like polygemcitabine undergo rapid intracellular degradation to generate active gemcitabine derivatives for enhanced cancer therapy. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
ConclusionIn conclusion, this study illustrates that the application and benefits of HS on reducing GI rectal dose endpoints and toxicities during prostate cancer RT can be reliably replicated in a community setting similar to centres participating in the randomised trial under high quality assurance trial monitoring.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
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Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
(copied from reddit) Hey guys, So I wanted to follow up on a previous thread I started, which discussed some obstacles and hardships I faced as an undergrad, which included losing my mom to cancer over the course of 2 years. In short, this left me broken mentally, physically, and a scar on my academic career. My GPA was significantly impacted and it decreased incredibly through those years, however, the past 3... What to do next? Graduate and kind of lost right now
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Thoracic surgeon and scientist Dr. Prasad Adusumilli at Memorial Sloan Kettering (MSK) Cancer Center believes customized gene therapy will soon change the way pleural mesothelioma is treated. Adusumilli, director of the Mesothelioma Program at MSK, has worked for a decade on developing tumor immunology for thoracic malignancies. He is currently the principal investigator of a phase I clinical trial involving specially prepared immune cells — chimeric antigen receptor (CAR) T cells — that have shown impressive efficacy with mesothelioma. “I think this is going to change the paradigm of treating mesotheliom...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
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