Choosing the Alternative

Since the initial demonstration of the fundamental impact of HLA compatibility in dictating the outcome of allogeneic hematopoietic stem cell transplantation (HSCT), efforts from the worldwide transplant community have been focused on two challenging and somewhat contradictory tasks: on the one hand, increasing the pool of volunteer stem cell donors to raise the chance of finding an acceptable match for patients in need of a transplant, and on the other hand, devising strategies to improve the feasibility and safety of HSCT from partially HLA-incompatible donors for all those patients that still do not find a match.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research