Glucosidase II beta subunit (GluII β) plays a role in autophagy and apoptosis regulation in lung carcinoma cells in a p53-dependent manner

ConclusionsOur data indicate that GluII β inhibition results in autophagy and apoptosis in lung carcinoma-derived cells, supporting the hypothesis that this enzyme may play a role in blocking these two tumor suppressive processes. Since blocking autophagy by lysosomal inhibitors enhanced the apoptosis-inducing effect of bromoconduritol, independent of p53 status, their combined use may hold promise for the treatment of cancer, particularly lung cancer.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research