Obesity is linked to lower counts and quality of sperm

Obese men are more likely to have few sperm of lower quality, according to new research. Sperm quality and count are the two primary male factors in couples' infertility.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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(American Society for Biochemistry and Molecular Biology) Proteomic analysis of oocytes from obese mice showed changes in a protein that promotes antioxidant production and may alter meiotic spindles.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Publication date: Available online 15 August 2018Source: SteroidsAuthor(s): Julius Fink, Masahito Matsumoto, Yoshifumi TamuraAbstractSedentary lifestyle and over-nutrition are the main causes of obesity and type 2 diabetes (T2D). However, the same causes are major triggers of hypogonadism. Many T2D patients show low testosterone levels while hypogonadal men seem to be prone to become diabetic. Testosterone plays a major role in the regulation of muscle mass, adipose tissue, inflammation and insulin sensitivity and is therefore indirectly regulating several metabolic pathways, while T2D is commonly triggered by insulin resi...
Source: Steroids - Category: Drugs & Pharmacology Source Type: research
ConclusionCompared to non-PCOS patients, PCOS patients had greater postoperative ΔBMI and %EWL at 1 year. The majority of patients becoming pregnant after VSG were previously nulliparous. This study shows that VSG is effective for weight loss in PCOS patients with obesity and may positively augment effect fertility rates.
Source: Obesity Surgery - Category: Surgery Source Type: research
CONCLUSIONS: Female genital tract infections, but not the comorbidities studied here, are associated with an increased risk of infertility.
Source: Clinics - Category: General Medicine Source Type: research
ConclusionVitamin D deficiency is highly prevalent in infertile PCOS women and there seems to be no association between hypovitaminosis D and the metabolic syndrome in the same population.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Recently published data suggests that male fertility has declined over the past four decades. The reasons for the decline are unclear with up to 50% of cases of male infertility remaining unexplained (idiopathic male infertility). Whilst environmental factors and rising rates of obesity have been implicated, there is now growing evidence that sleep disturbance may be an independent causative factor. Indeed, the prevalence of sleep disturbance appears to be increasing in parallel with deterioration in population sperm quality, a commonly used surrogate marker of male fertility.
Source: Sleep Medicine Reviews - Category: Sleep Medicine Authors: Tags: Theoretical Review Source Type: research
AbstractPurposeTo identify demographic, (bio)physical, behavioral, and psychological determinants of successful lifestyle change and program completion by performing a secondary analysis of the intervention arm of a randomized-controlled trial, investigating a preconception lifestyle intervention.MethodsThe 6-month lifestyle intervention consisted of dietary counseling, physical activity, and behavioral modification, and was aimed at 5 –10% weight loss. We operationalized successful lifestyle change as successful weight loss (≥ 5% weight/BMI ≤ 29 kg/m2), weight loss in kilograms, a red...
Source: European Journal of Nutrition - Category: Nutrition Source Type: research
Authors: Artini PG, Obino MER, Sergiampietri C, Pinelli S, Papini F, Casarosa E, Cela V Abstract INTRODUCTION: Polycystic ovary syndrome (PCOS) is a common cause of female infertility affecting multiple aspects of a women's health. Areas covered: The aim of this review is to summarize the existing evidence on the treatment of PCOS patients and to examine the actual available therapies to overcome the problem of infertility and improve the outcome of pregnancy. We analyse different treatment strategies such as lifestyle modification, bariatric surgery, insulin sensitizing agents, inositol, clomiphene citrate (CC), a...
Source: Expert Review of Endocrinology and Metabolism - Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research
Abstract Context: Women with PCOS are at increased risk for pregnancy complications possibly related to pre-existing obesity and potentially to excessive gestational weight gain (GWG). Objectives: To assess the contributions of pre-existing diagnosis and preconception weight on GWG and perinatal outcomes. Research Design and Methods: Prospective cohort study of singleton pregnancies in PCOS(N =164) and ovulatory controls(N = 176) conceiving from infertility treatment. Main Outcome measures: GWG, birthweight, pregnancy complications. Results: From pre-conception baseline, normal-weight PCOS women gai...
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research
Publication date: Available online 29 July 2018Source: Molecular and Cellular EndocrinologyAuthor(s): Noah J. Levi, Christopher W. Wilson, Graham A.J. Redweik, Nathan W. Gray, Cody W. Grzybowski, Joseph A. Lenkey, Anthony W. Moseman, Alec D. Bertsch, Nhien Dao, Heidi E. WalshAbstractObesity is a risk factor for infertility, but mechanisms underlying this risk are unclear. Fertility is regulated by hypothalamic gonadotropin-releasing hormone, encoded by the Gnrh1 gene. Because obesity promotes endoplasmic reticulum (ER) stress, we sought to determine how tunicamycin-induced ER stress affected Gnrh1 gene expression in the mo...
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research
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