The addition of tramadol to the standard of IV acetaminophen and morphine infusion for postoperative analgesia in neonates offers no clinical benefit: a randomized placebo‐controlled trial

ConclusionTramadol's addition to standard analgesia in this small group of postsurgical neonates did not appear to have any positive effect on time to extubation, morphine or midazolam exposure, or pain scores. This questions the benefit of tramadol for postsurgical neonates. Importantly, no seizures occurred in these ill neonates who may potentially be at greater risk of tramadol toxicity compared with adults.

Source: Pediatric Anesthesia - July 14, 2014 Category: Anesthesiology Authors: Monika Olischar, Greta M. Palmer, Francesca Orsini, Andrew J. Davidson, Elizabeth J. Perkins, Katherine J. Lee, Neil J. Everest, Noel E. Cranswick, Rod W. Hunt Tags: Original Article Source Type: research