Poster 68: Urinary Symptoms and Urinalysis do not Predict Uropathogens on Pyrosequencing in Patients with Spinal Cord Injury
Emma Nally: I Have No Relevant Financial Relationships To Disclose
Monosynaptic rabies tracing can be used to map inputs to stem cell ‐derived neurons grafted to models of neurodegenerative disease and injury. These studies indicate that graft neurons receive anatomically‐appropriate inputs, but it remains to be determined whether those inputs are necessary for functional recovery. Next‐generation rabies tracing is poised to address this outstanding question, which may aid ongoing translational efforts. ABSTRACTFetal neural progenitor grafts have been evaluated in preclinical animal models of spinal cord injury and Parkinson's disease for decades, but the initial reliance on primary...
In conclusion, the cPAM induces an effective treatment of SCI by the lesion tissue specific delivery of the prodrug polymer via its robust scar binding effect, making the scar tissue a drug releasing platform for sustained treatment of SCI.
This study aimed to investigate the association between traumatic spinal cord injury (TSCI) and the risk of affective and other psychiatric disorders, and the role of the rehabilitation therapies. METHODS: In this population-based, retr...
Conclusions: Our review reported some potential substances that may improve neurological outcome in acute SCI: MP, vitamin D associated with progesterone, and erythropoietin. Their potential benefits were modest in the evaluated studies, requiring further randomized clinical trials with large samples of patients, without statistical artifacts, for routine clinical use. Furthermore, potential adverse effects must be considered with the use of neuroprotective agents in SCI. Until then, the use of these substances may be experimental or restricted to specific clinical situations.
Publication date: Available online 25 February 2020Source: NeuroImage: ClinicalAuthor(s): Michela Azzarito, Maryam Seif, Sreenath Kyathanahally, Armin Curt, Patrick Freund
CONCLUSIONS: Increase of miR-34a suppresses neuronal apoptosis and alleviates microglia inflammation by negatively targeting the Notch pathway, thereby improving neural recovery and locomotor function. PMID: 32096191 [PubMed - in process]
Spinal Cord, Published online: 26 February 2020; doi:10.1038/s41393-020-0444-4Outpatient and community care for preventing pressure injuries in spinal cord injury. A qualitative study of service users’ and providers’ experience
CONCLUSION: NMDA receptor antagonists, especially amantadine, may ameliorate SCI by inducing angiogenesis, affecting inflammation and apoptosis. It inhibits oxidative stress and the signaling pathways following SCI in rats. PMID: 32091112 [PubMed - in process]
The American Congress of Rehabilitation Medicine (ACRM) offers an opportunity for members to be the guest editor of a Supplement to its journal, the Archives of Physical Medicine and Rehabilitation (Archives). The goal of the ACRM supplements is to publish high quality scientific manuscripts, which are thematically organized and of interest to ACRM members and to the general readership of the Archives. We are interested in proposals in all fields of rehabilitation, but especially those of interest to the ACRM membership as indicated by the existence of special interest and networking groups for brain injury, spinal cord in...
The recruitment of immune system cells into the central nervous system (CNS) has a profound effect on the outcomes of injury and disease. Glia-derived chemoattractants, including chemokines, play a pivotal rol...
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