Poster 95: Functional Decline in Multiple Sclerosis: Effect of Etiology on the Outcome of Rehabilitation

Kanakadurga Poduri: I Have No Relevant Financial Relationships To Disclose
Source: PM and R - Category: Rehabilitation Authors: Source Type: research

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This study aimed to investigate the in vitro effects of the Apigenin 3-Acetate on Th17 cells of MS patients and compare its efficacy with Apigenin and Methyl Prednisolone Acetate.IC50 for Apigenin 3-Acetate, and Methyl Prednisolone Acetate were determined using three healthy volunteers. The peripheral blood mononuclear cells (PBMCs) of five MS patients were isolated and co-cultured with a selected dose of Apigenin, Apigenin 3-Acetate, and Methyl Prednisolone Acetate for 48 hr, and then theproliferation of Th17 cells in isolated PBMCs was assessed by flow cytometry. The levels of RAR-related orphan receptor (RORC) and IL-17...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
Conditions:   Multiple Sclerosis;   Neurologic Symptoms;   Menstrual Cycle Interventions:   Other: Position Sense;   Other: Balance;   Other: Dual Task Performance Sponsor:   Ankara Yildirim Beyaz─▒t University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Spastic Parapareses Intervention:   Device: Transcutaneous Spinal Direct Current Stimulation Sponsor:   Lebanese American University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Multiple Sclerosis Intervention:   Sponsors:   BeCare Link LLC;   Yale University Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Background: Patients with multiple sclerosis (MS) experience progressive thinning in optical coherence tomography (OCT) measures of neuroaxonal structure regardless of optic neuritis history. Few prospective studies have investigated the effects of disease-modifying therapies on neuroaxonal degeneration in the retina. Alemtuzumab is a monoclonal antibody shown to be superior to interferon β-1a in treating relapsing–remitting MS (RRMS). The purpose of this study was to assess the effects of alemtuzumab and first-line injectable treatments on OCT measures of neuroaxonal structure including peripapillary retinal ...
Source: Journal of Neuro-Ophthalmology - Category: Opthalmology Tags: Original Contribution Source Type: research
Publication date: Available online 27 February 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Tuba Rashid Khan, Cynthia Wang
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 26 February 2020Source: NeuroImage: ClinicalAuthor(s): J.A. Kim, R.B. Bosma, K.S. Hemington, A. Rogachov, N.R. Osborne, J.C. Cheng, J. Oh, B.T. Dunkley, K.D. Davis
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Publication date: Available online 26 February 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Paula Teixeira Marques, Cláudia Suemi Kamoi Kay, Flavia Machado Alves Basílio, Rosângela Lameira Pinheiro, Lineu Cesar Werneck, Paulo Jose Lorenzoni, Rosana Herminia Scola
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
(University of California - San Diego) An international team of scientists, led by UC San Diego researchers, has developed a new, multi-sensor tool that measures subtle changes in multiple sclerosis patients, allowing physicians to more frequently and more quickly respond to changes in symptoms or patient condition.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Nature Reviews Neurology, Published online: 26 February 2020; doi:10.1038/s41582-020-0329-3A new study has identified an association between socioeconomic status and the risk of disability in individuals with multiple sclerosis. The findings highlight the importance of collecting large, structured datasets for the study of modifiable risk factors.
Source: Nature Reviews Neurology - Category: Neurology Authors: Source Type: research
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