BDNF haplo ‐insufficiency impairs high‐frequency cortical oscillations in mice

This study investigated the influence of BDNF deficiency and NMDA receptor hypofunction on electrophysiological responses to brief acoustic stimuli. Adult BDNF heterozygote (BDNF+/‐) and wildtype littermate C57Bl/6J mice were surgically implanted with EEG recording electrodes. All mice underwent EEG recording sessions to measure ongoing and auditory‐evoked electrophysiological responses following treatment with MK‐801 (0.3mg/kg ip) or vehicle. Western blotting on post‐mortem cortical tissue assessed parvalbumin and GAD67 expression – markers of interneurons which are involved in the generation of gamma oscillations. Compared to wildtype controls, BDNF+/‐ mice exhibited markedly dampened electrophysiological responses to auditory stimuli, including reductions in the amplitude of multiple components of the event‐related potential and auditory‐evoked oscillations, as well as reduced ongoing cortical gamma oscillations. MK‐801 elevated ongoing gamma power but suppressed evoked gamma power, and this was observed equally across genotypes. BDNF+/‐ mice also displayed reductions in parvalbumin, but not GAD67 expression. We conclude that reduced BDNF expression leads to impairments in the generation of high‐frequency neural oscillations, but this is not synergistic with NMDA receptor hypofunction. Reduced parvalbumin expression associated with BDNF haplo‐insufficiency may provide a molecular explanation for these electrophysiological deficits. This article is p...
Source: European Journal of Neuroscience - Category: Neuroscience Authors: Tags: Special Issue Article Source Type: research