A case-control study of hormonal exposures as etiologic factors for ALS in women: Euro-MOTOR

Conclusions:
This large case-control study across 3 different countries has demonstrated an association between exogenous estrogens and progestogens and reduced odds of ALS in women. These results are at variance with previous findings, which may be partly explained by differential regulatory, social, and cultural attitudes toward pregnancy, birth control, and HRT across the countries included. Our results indicate that hormonal factors may be important etiologic factors in ALS; however, a full understanding requires further investigation.

Source: Neurology - September 18, 2017 Category: Neurology Authors: Rooney, J. P. K., Visser, A. E., D'Ovidio, F., Vermeulen, R., Beghi, E., Chio, A., Veldink, J. H., Logroscino, G., van den Berg, L. H., Hardiman, O., For the Euro-MOTOR Consortium Tags: Amyotrophic lateral sclerosis, Case control studies, Risk factors in epidemiology ARTICLE Source Type: research