Cognition and gray and white matter characteristics of presymptomatic C9orf72 repeat expansion
Conclusions:
This study demonstrates that a decline in cognitive functioning, white matter integrity, and gray matter volumes are present in presymptomatic C9orf72RE carriers. These findings suggest that neuropsychological assessment, T1-weighted MRI, and diffusion tensor imaging might be useful to identify early biomarkers in the presymptomatic stage of FTD or amyotrophic lateral sclerosis.
Source: Neurology - Category: Neurology Authors: Papma, J. M., Jiskoot, L. C., Panman, J. L., Dopper, E. G., den Heijer, T., Donker Kaat, L., Pijnenburg, Y. A. L., Meeter, L. H., van Minkelen, R., Rombouts, S. A. R. B., van Swieten, J. C. Tags: DWI, Volumetric MRI, Frontotemporal dementia ARTICLE Source Type: research