Genetic epilepsy with febrile seizures plus: Refining the spectrum

Conclusion:
As 37/409 (9%) affected individuals have focal epilepsies, we suggest that GEFS+ be renamed genetic epilepsy with febrile seizures plus rather than generalized epilepsy with febrile seizures plus. The phenotypic overlap between GEFS+ and the classic generalized epilepsies is considerably greater than first thought. The clinical and molecular data suggest that the 2 major groups of generalized epilepsies share genetic determinants.

Source: Neurology - September 18, 2017 Category: Neurology Authors: Zhang, Y.-H., Burgess, R., Malone, J. P., Glubb, G. C., Helbig, K. L., Vadlamudi, L., Kivity, S., Afawi, Z., Bleasel, A., Grattan-Smith, P., Grinton, B. E., Bellows, S. T., Vears, D. F., Damiano, J. A., Goldberg-Stern, H., Korczyn, A. D., Dibbens, L. M., Tags: All Genetics ARTICLE Source Type: research