Abstract 012: Vascular Smooth Muscle ADAM17 Contributes to Angiotensin II-induced Abdominal Aortic Aneurysm Formation but Not Hypertension in Mice Session Title: Renin Angiotensin System I

Over activation of the renin angiotensin II (AngII) system has been implicated in abdominal aortic aneurysm (AAA). However, the precise molecular mechanism(s) by which AngII promotes AAA remain insufficiently understood, which hinders pharmacological treatment. At a past AHA conference, we reported critical roles for the metalloprotease, ADAM17, and downstream EGFR transactivation, in the development of AngII-induced AAA in mice treated with a lysyl oxidase inhibitor beta-aminopropionitrile (BAPN). Specifically, we demonstrated that in the mouse AngII-induced AAA was attenuated by either deletion of ADAM17 in VSMC or treatment with an EGFR inhibitor erlotinib. To better understand the clinical relevance of these findings, we studied the effect of an ADAM17 inhibitory antibody (A9B8), which recognizes both human and mouse ADAM17. Eight-week-old male C57BL6 mice were given AngII 1000 ng/kg/min via osmotic minipumps for 4 consecutive weeks and BAPN 150 mg/kg/day in drinking water for the initial 2 weeks. Additionally, mice were given 10 mg/kg/day A9B8 or control human IgG2 i.p. injection at day 1, 7, 14 and 21. As an index for AAA formation, abdominal aortic internal diameter was measured by ultrasound at day 0, 14, 21 and 28. Aortic external diameter was also measurement at day 28. AngII/BAPN treated mice given control IgG2 have a mortality rate of 46.2% due to aortic rupture/dissection. Mortality rate in mice given A9B8 was reduced to 23.1% (n=13). Surviving IgG2 treated mice ...
Source: Hypertension - Category: Cardiology Authors: Tags: Oral Abstract Presentations Source Type: research

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Conclusions. ASI was a significant predictor of both AAA development and aortic growth of>5 mm for both men and women, but not a better predictor of either outcomes compared to the AD. The role of ASI compared to the AD as a predictor of AAA development seems to be limited. PMID: 31909634 [PubMed - as supplied by publisher]
Source: Scandinavian Cardiovascular Journal - Category: Cardiology Tags: Scand Cardiovasc J Source Type: research
Resumo O aneurisma de art éria poplítea (AAP) é o mais frequente dos aneurismas periféricos, correspondendo a 85% do total de aneurismas. Normalmente, são assintomáticos, e o diagnóstico, em geral, é feito por meio do exame físico, tendo uma maior incidência no sexo masculino e em idosos. São bilaterais em 50% dos casos e, em 60% das vezes, estão associados a aneurisma de aorta abdominal. Apresentamos um paciente do sexo masculino com 72 anos de idade, com duas massas pulsáteis em ambas as regiões poplíteas, assintom&aac...
Source: Jornal Vascular Brasileiro - Category: Surgery Source Type: research
CONCLUSION: ACUTE ABDOMEN sonographic approach in acute abdomen can play an important role in ruling out critical diagnosis, and can guide emergency physician or any critical care physician in patient management. PMID: 31544223 [PubMed]
Source: Pain Physician - Category: Anesthesiology Authors: Tags: Ultrasound J Source Type: research
ConclusionACUTE ABDOMEN sonographic approach in acute abdomen can play an important role in ruling out critical diagnosis, and can guide emergency physician or any critical care physician in patient management.
Source: Critical Ultrasound Journal - Category: Radiology Source Type: research
nhainen A Abstract Background: The aims of this study were to determine the prevalence of screening-detected subaneurysmal aorta (SAA), i.e. an aortic diameter of 2.5-2.9 cm, its associated risk factors, and natural history among 65-year-old men. Methods: A total of 14,620 men had their abdominal aortas screened with ultrasound and completed a health questionnaire containing information on smoking habits and medical history. They were categorized based on the aortic diameter: normal aorta (
Source: Upsala Journal of Medical Sciences - Category: General Medicine Authors: Tags: Ups J Med Sci Source Type: research
A 75-year-old morbidly obese man presented with increasing diameter of a known abdominal aortic aneurysm (AAA) and right common iliac artery aneurysm. He was diagnosed with these aneurysms at the age of 69  years while undergoing computed tomography for evaluation of pancreatic cancer. At the time of diagnosis, the AAA diameter was 3.9 cm. His past medical history was significant for hypertension and hyperlipidemia. He was observed with serial aortoiliac duplex ultrasound scans. By November 2018 (6  years after the original diagnosis), the AAA diameter increased to 6.3 cm and the right common iliac arte...
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Vascular images Source Type: research
CONCLUSION: There is an increased prevalence of AAA in patients with ΙΗ, especially in smokers, with hypertension and with bilateral and/or direct hernia. Hence, periodic ultrasonound may play an important role in screening and early diagnosis of AAA in these patients. PMID: 30697034 [PubMed - as supplied by publisher]
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research
Fagnano Abdominal aortic aneurysm (AAA) represents an important public health problem with a prevalence between 1.3% and 12.5%. Several population-based randomized trials have evaluated ultrasound screening for AAA providing evidence of a reduction in aneurysm-related mortality in the screened population. The aim of our study was to perform a systematic review and meta-analysis of the risk factors for AAA. We conducted a systematic review of observational studies and we performed a meta-analysis that evaluated the following risk factors: gender, smoking habits, hypertension, coronary artery disease and family history o...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
ñanás-Mastral A Abstract OBJECTIVE: To determine the usefulness of ultrasound examination in Primary Care (PC) for the detection of abdominal aortic aneurysm (AAA) in male patients from 65-75 years old, as well as the consistency between observers on the diagnosis between general practitioners and the reference specialty in this area, Vascular Surgery. To estimate the prevalence of AAA in that population and its association with risk factors. DESIGN: Cross-sectional descriptive study. LOCATION: Healthcare Centres of Coto and Calzada II (Gijón, Spain). PARTICIPANTS: Males born be...
Source: Atencion Primaria - Category: Primary Care Authors: Tags: Aten Primaria Source Type: research
CONCLUSIONS: The prevalence of AAA in men aged 65 years and older is seemingly larger than in previously conducted studies, while among men 60-64 years of age and women aged ≥ 65 it is similar. Older age, smoking, and a history of MI/ACS were the most important risk factors of AAA occurrence. PMID: 28394003 [PubMed - indexed for MEDLINE]
Source: Kardiologia Polska - Category: Cardiology Authors: Tags: Kardiol Pol Source Type: research
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