Amgen and Allergan ’s anti-cancer biosimilar Mvasi receives FDA approval

The US Food and Drug Administration (FDA) has approved Mvasi (bevacizumab-awwb) for the treatment of five types of cancer.
Source: Pharmaceutical Technology - Category: Pharmaceuticals Source Type: news

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Meagan Bechtold, 27, of Las Vegas, developed a hacking cough in March last year, which doctors wrote off as a bad cold, allergies or bronchitis. A CT scan later revealed she had Hodgkin’s lymphoma.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
The National Institutes of Health (NIH) would receive $34.4 billion in FY 2020, roughly $4.7 billion or 13 percent below the levels enacted by Congress for FY 2019, according to the President’s Budget released on March 11. The budget for NIH includes $492 million in funding made available through the 21st Century Cures Act and $150 million in mandatory funding. The leading biomedical research agency in the world would receive budget cuts across the board. All NIH centers are slated for budget reductions: National Cancer Institute: -8.7 percent National Heart, Lung, and Blood Institute: -14 percent National Inst...
Source: Public Policy Reports - Category: Biology Authors: Source Type: news
It’s been 40 years since Norman Cousins published his classic An Anatomy of an Illness, in which he documents curing himself with a high dose of vitamin C and a continuous stream of humorous films. Since then research has further established the medicinal benefits of laughter, helping everything from Alzheimer’s disease and allergies to backaches and muscle cramping. Following one of his studies on the benefits of laughter, Dr. Michael Miller said he envisioned a time when physicians might recommend that everyone get 15 to 20 minutes of laughter in a day much like physicians recommend regular exercise. Not...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Happiness Health-related Mental Health and Wellness Psychology Research Stress Fun Humor Laughter Source Type: blogs
Rituximab is a chimeric monoclonal anti-CD20 antibody with wide use in cancer (lymphoma) and connective tissue diseases (rheumatoid arthritis, and vasculitis)1. Hypersensitivity reactions to rituximab can range from type I IgE-mediated reaction (urticaria, shortness of breath, hypotension, or anaphylaxis), to cytokine-mediated reaction (fevers, chills, rigors), or a mix of both, thus limiting the use of rituximab as first line therapy for many cases. Desensitization is a new therapeutic approach which can be performed with rituximab to offset these reactions.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Challenging Clinical Cases Source Type: research
A fourth-quarter earnings miss and the uncertainty around an upcoming FDA advisory panel meeting on breast implants sent Sientra (NSDQ:SIEN) shares down precipitously today. The Santa Barbara, Calif.-based medical aesthetics company’s losses widened 38.1% to -$24.6 million, or 86¢ per share, on sales growth of 71.9% to $19.0 million for the three months ended Dec. 31, 2018, compared with Q4 2017. Analysts on Wall Street were looking for losses of -68¢. Full-year losses were up 29.0% to -$82.6 million, or -$3.25 per share, on sales growth of 86.4% to $68.1 million compared with the prior year, Sientra said. ...
Source: Mass Device - Category: Medical Devices Authors: Tags: Cosmetic/Aesthetic MassDevice Earnings Roundup Wall Street Beat Women's Health Sientra Source Type: news
Advertisements suggesting that personalized cancer treatment can improve survival or even offer a cure are not realistic for all patients and are unethical.Medscape Business of Medicine
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Family Medicine/Primary Care Commentary Source Type: news
This study showed that there are no significant differences in the level of immunogenicity between both enzymes, while asparaginase from E. coli presented a higher relative frequency of allergenic epitopes. These results are consistent with previously published reports. However, from a structural point of view, in our knowledge, this is the first research describing the structural antigenic determinants that contribute to the hypersensibility response to this treatment.
Source: Biologicals - Category: Biology Source Type: research
AbstractImmune-checkpoint inhibition (ICI) treatments improve outcomes for metastatic melanoma; however,>  60% of treated patients do not respond to ICI. Current biomarkers do not reliably explain ICI resistance. Given the link between ICI and autoimmunity, we investigated if genetic susceptibility to autoimmunity modulates ICI efficacy. In 436 patients with metastatic melanoma receiving single line I CI or combination treatment, we tested 25 SNPs, associated with>  2 autoimmune diseases in recent genome-wide association studies, for modulation of ICI efficacy. We found that rs17388568—a risk vari...
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research
This study showed that there are no significant differences in the level of immunogenicity between both enzymes, while asparaginase from E. coli presented a higher relative frequency of allergenic epitopes. These results are consistent with previously published reports. However, from a structural point of view, in our knowledge, this is the first research describing the structural antigenic determinants that contribute to the hypersensibility response to this treatment. PMID: 30871932 [PubMed - as supplied by publisher]
Source: Biologicals : Journal of the International Association of Biological Standardization - Category: Biotechnology Authors: Tags: Biologicals Source Type: research
They say they were not sufficiently informed of risks associated with Allergan Related items fromOnMedica Cancer patients using complementary meds die sooner Only a third of women with regular bloating would see their GP Social media could help raise breast screening take-up Exercise and psychological treatments cut cancer fatigue Nurse guidance published on cervical cancer and HPV
Source: OnMedica Latest News - Category: UK Health Source Type: news
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