Antitumor platinum(IV) derivatives of carboplatin and the histone deacetylase inhibitor 4-phenylbutyric acid.
Antitumor platinum(IV) derivatives of carboplatin and the histone deacetylase inhibitor 4-phenylbutyric acid. J Inorg Biochem. 2017 Sep 10;177:1-7 Authors: Almotairy ARZ, Gandin V, Morrison L, Marzano C, Montagner D, Erxleben A Abstract Five new platinum(IV) derivatives of carboplatin each incorporating the histone deacetylase inhibitor 4-phenylbutyrate in axial position were synthesized and characterized by (1)H and (195)Pt NMR spectroscopy, electrospray ionization mass spectrometry and elemental analysis, namely cis,trans-[Pt(CBDCA)(NH3)2(PBA)(OH)] (1), cis,trans-[Pt(CBDCA)(NH3)2(PBA)2] (2), cis,trans-[Pt(CBDCA)(NH3)2(PBA)(bz)] (3), cis,trans-[Pt(CBDCA)(NH3)2(PBA)(suc)] (4) and cis,trans-[Pt(CBDCA)(NH3)2)(PBA)(ac)] (5) (PBA=4-phenylbutyrate, CBDCA=1,1-cyclobutane dicarboxylate, bz=benzoate, suc=succinate and ac=acetate). The reduction behavior in the presence of ascorbic acid was studied by high performance liquid chromatography. The cytotoxicity against a panel of human tumor cell lines, histone deacetylase (HDAC) inhibitory activity, cellular accumulation and the ability to induce apoptosis were evaluated. The most effective complex, compound 3, was found to be up to ten times more effective than carboplatin and to decrease cellular basal HDAC activity by approximately 18% in A431 human cervical cancer cells. PMID: 28918353 [PubMed - as supplied by publisher]
Publication date: August 2020Source: Biomedicine &Pharmacotherapy, Volume 128Author(s): Qingzhi Guo, Li Li, Qimei Bo, Li Chen, Li Sun, Hongtang Shi
AbstractOver 74,000 women in the United States are diagnosed annually with endometrial or cervical cancers and experience significant treatment-related difficulties with body image, sexuality, and sexual functioning. The aims of the research were to examine relationships among body image, sexuality, and sexual functioning, and to understand women ’s views of these concepts. A novel theoretical framework encompassing these three concepts and contextual variables guided the research. A non-experimental cross-sectional pilot study was conducted with pre-menopausal women in an academic medical center who had stages I&nda...
High-risk human papillomavirus (HPV) infection is an essential factor for the development of cervical cancer. HPV18 is the second most common carcinogenic HPV type following HPV16, but the lineages of HPV18 ha...
Lysine acetylation is a post-translational modification that regulates a diversity of biological processes, including cancer development.
Publication date: Available online 23 May 2020Source: Practical Radiation OncologyAuthor(s): Kelly Kisling, Carlos Cardenas, Brian M. Anderson, Joy Zhang, Anuja Jhingran, Hannah Simonds, Peter Balter, Rebecca M. Howell, Kathleen Schmeler, Beth M. Beadle, Laurence Court
Publication date: Available online 23 May 2020Source: Journal of the American Society of CytopathologyAuthor(s): Ritu Nayar, David C. Chhieng, Barbara Crothers, Teresa M. Darragh, Diane D. Davey, Carol Eisenhut, Robert Goulart, Eric C. Huang, Sana O. Tabbara
Telemedicine and telehealth (TM/TH) are the 2 terms used interchangeably focusing on the delivery of health care services at a long distance using telecommunication technology. TM/TH has several gynecologic applications, including the well-woman visits, preventive care, preconception counseling, family planning including contraception and medical abortion, infertility workup, teleradiology, cervical cancer screening and colposcopy, mental health, and telesurgery. The goals of TM/TH are not only improving quality of health care in patients and building a virtual community of physicians but also increasing convenience, effic...