Comparative evaluation of the effects of ezetimibe and atorvastatin on serum lipid profile changes in experimental hypercholesterolemia in cat

In conclusion, ezetimibe was more effective than atorvastatin in reducing cholesterol.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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ConclusionsAlthough most high-risk patients with T2D and CV disease were on lipid-lowering therapy, only 1:3 had LDL-C 
Source: American Heart Journal - Category: Cardiology Source Type: research
Publication date: Available online 12 November 2019Source: American Heart JournalAuthor(s): Franck Boccara, Princy Kumar, Bruno Caramelli, Alexandra Calmy, J. Antonio G. López, Sarah Bray, Marcoli Cyrille, Robert S. RosensonBackgroundPeople living with human immunodeficiency virus (PLHIV) are at higher risk of atherosclerotic cardiovascular disease (ASCVD) due to traditional and HIV- or antiretroviral treatment (ART)-related risk factors. The use of high-intensity statin therapy is often limited by comorbidities and drug–drug interactions with ART. Herein, we present the design and baseline characteristics of ...
Source: American Heart Journal - Category: Cardiology Source Type: research
Publication date: Available online 13 November 2019Source: Redox BiologyAuthor(s): Sofia-Iris Bibli, Jiong Hu, Matthias S. Leisegang, Janina Wittig, Sven Zukunft, Andrea Kapasakalidi, Beate Fisstlhaller, Diamantis Tsilimigras, Georgios Zografos, Konstantinos Filis, Ralf P. Brandes, Andreas Papapetropoulos, Fragiska Sigala, Ingrid FlemingAbstractCystathionine γ lyase (CSE) is the major source of hydrogen sulfide-derived species (H2Sn) in endothelial cells and plays an important role in protecting against atherosclerosis. Here we investigated the molecular mechanisms underlying the regulation of CSE expression in endot...
Source: Redox Biology - Category: Biology Source Type: research
A build-up of cholesterol in the brains of people with a severe form of epilepsy can cause prolonged seizures, but it may be possible to treat this with statins
Source: New Scientist - Health - Category: Consumer Health News Source Type: research
This randomized clinical trial compares the efficacy of bempedoic acid, an experimental drug that inhibits an enzyme upstream of HMG-CoA reductase, vs placebo for lowering levels of low-density lipoprotein cholesterol (LDL-C) in patients at high cardiovascular risk with ongoing hypercholesterolemia receiving maximally tolerated lipid-lowering therapy.
Source: JAMA - Category: General Medicine Source Type: research
Since the report of the first expert panel of the National Cholesterol Education Program in 1988, effectively the first contemporary professional cholesterol guidelines in the United States, lowering of low-density lipoprotein cholesterol (LDL-C) levels has been a cornerstone of atherosclerotic cardiovascular disease (ASCVD) prevention. Consistent with classical and genetic epidemiologic studies implying a causal relationship between LDL-C and ASCVD, multiple randomized clinical trials have consistently observed proportional relationships between LDL-C lowering and ASCVD risk reduction from statins. More recently, these fi...
Source: JAMA - Category: General Medicine Source Type: research
Abstract Lipophilicity of statins has been linked to extrahepatic cells penetration and inhibition of isoprenoid synthesis and coenzyme Q10 which may affect myocardial contraction. Whether statins lipophilicity affects the risk of cardiovascular disease development in patients under dialysis is unclear. This population-based study included 114,929 patients undergoing chronic dialysis, retrieved from the Registry for Catastrophic Illness Patients from the National Health Insurance Research Database in Taiwan from 2000 to 2013. Statins were initiated after dialysis and classified into hydrophilic and lipophilic by t...
Source: Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Authors: Tags: Clin Pharmacol Ther Source Type: research
Neither vitamin D3 nor omega-3 fatty acid supplements cut CKD risk in people with type 2 diabetes over five years Related items fromOnMedica UK research reveals racial inequalities in diabetes care Statins of small and uncertain benefit in primary prevention Should we recognise obesity as a disease? Sugar not saturated fat is the major issue for CVD WHO dietary fat guidance fails to consider crucial evidence
Source: OnMedica Latest News - Category: UK Health Source Type: news
Switch from target-based to risk-based approach seems to have improved cholesterol – notably in those taking statins Related items fromOnMedica UK research reveals racial inequalities in diabetes care Statins of small and uncertain benefit in primary prevention Pharmacists could offer high-dose statins direct to patients WHO dietary fat guidance fails to consider crucial evidence Vitamin D supplements do not confer cardiovascular protection
Source: OnMedica Latest News - Category: UK Health Source Type: news
Health systems should plan now for considerable impact of AMD on healthcare resources Related items fromOnMedica Statins of small and uncertain benefit in primary prevention Social prescribing can free up GPs ’ time and save resources Poor people have worse end-of-life care Chronic stress linked to hypertension risk in black US adults Prioritise and fund prevention to save lives and NHS, warn doctors
Source: OnMedica Latest News - Category: UK Health Source Type: news
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