Glucagon Decreases IGF-1 Bioactivity in Humans, Independently of Insulin, by Modulating Its Binding Proteins.

Conclusions: Our data point to the glucagon-induced decrease in bioactive IGF-1 levels as a mechanism through which glucagon induces GH secretion. This insulin-independent reduction is related to increased IGFBP-1 and IGFBP-2 levels, which are most likely mediated via activation of the FOXO/mTOR (mechanistic target of rapamycin) pathway.
PMID: 28911141 [PubMed - in process]

Source: The Journal of Clinical Endocrinology and Metabolism - September 1, 2017 Category: Endocrinology Authors: Sarem Z, Bumke-Vogt C, Mahmoud AM, Assefa B, Weickert MO, Adamidou A, Bähr V, Frystyk J, Möhlig M, Spranger J, Lieske S, Birkenfeld AL, Pfeiffer AFH, Arafat AM Tags: J Clin Endocrinol Metab Source Type: research