For Irritating Itch, a Promising Option Under Scrutiny For Irritating Itch, a Promising Option Under Scrutiny
Investigational serlopitant afforded clinical trial patients quick relief for a variety of pruritis-characterized diseases.Medscape Medical News
On the eve of Memorial Day weekend, Jennifer Slone wants you to know that bug bites are more than just itchy. They can be deadly.
Itch is a somatosensory modality that serves to alert the organism to harmful elements removable by scratching, such as parasites and chemical irritants. Recently, ablation or silencing of neuropeptide Y (NPY)-expressing spinal interneurons was reported to selectively enhance mechanical itch whereas chemical itch was unaffected. We have examined the effect of activating the NPY/Y1 receptor system on scratch behavior in mouse. We found that intrathecal administration of the Y1 agonist [Leu31,Pro34]-NPY (LP-NPY) attenuated itch behavior induced by application of 0.07 g von Frey filament in the nape of the neck, compared to s...
Children with eczema whose bath water contains added moisturizers may get no more relief from the itchy skin condition than they would without the extra bath products, a study suggests.Reuters Health Information
If you have mesothelioma and you’ve already received standard-of-care therapies, you may be considering an immunotherapy clinical trial. If you’re considering this option, a free immunotherapy teleconference is a great place to learn more. CancerCare recently hosted two one-hour education workshops featuring panels of immunotherapy experts. Part I of the teleconference presented an overview of immunotherapy. Part II of the teleconference, which is available online for free, focused exclusively on immunotherapy side effects. Understanding these issues and the role each patient plays in managing their own side ef...
Cooling is an effective temporary remedy for itch, bringing welcome relief to itchy insect bites, nettle stings, poison ivy, atopic dermatitis, and psoriasis. Menthol, causing a cooling sensation, has similar itch-relieving effects. Palkar et al. demonstrate that TRPM8, a menthol- and cold-activated ion channel, is essential for cooling to relieve itch, suggesting that pharmacologic TRPM8 activation should be explored further as an antipruritic strategy.
Updated Date: May 21, 2018 EST
CONCLUSION: Taken together, these results thus defined a novel backbone structure for small molecule drug design targeting ASIC3 channels to treat pain-related diseases. PMID: 29781252 [PubMed - as supplied by publisher]
Discussion: Vesicular pattern in GD is described exclusively from a histopathological point of view, and it is defined as the presence of an intraepidermal vesicle filled with plasma and with dyskeratotic cells in the upper part of the vesicle. After reviewing all the described cases, pseudoherpetic GD presents the same histopathological features than vesicular GD, but authors paid attention to the presence of grouped acantholytic cells mimicking multinucleated cells of herpes infection. The authors consider that the so-called pseudoherpetic GD is a vesicular GD, where clinical suspicion of varicella raises this differen...
(Reuters Health) - Children with eczema whose bath water contains added moisturizers may get no more relief from the itchy skin condition than they would without the extra bath products, a recent experiment suggests.
Updated Date: May 18, 2018 EST