Early life physical activity may prevent cognitive decline

A new study in rodents shows how physical exercise in early life creates a cognitive reserve that improves cognition and neuronal activity in later years.
Source: Parkinson's Disease News From Medical News Today - Category: Neurology Tags: Neurology / Neuroscience Source Type: news

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PARKINSON ’S disease is a condition that affects parts of the brain and the nervous system. The main symptoms are related to the body’s movement, with shaking in the hands being the most well-known. But people may get other symptoms that aren’t related to movement. There are seven of these to watch out for.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Conclusion: These results suggest that iPSC-derived astrocytes resemble human commercial astrocytes validating the differentiating protocol used.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
In this study, we examine multiple mitochondrial pathways of amyloid toxicity in neuronal and cerebral endothelial cells (ECs), and evaluate CAIs methazolamide (MTZ) and, for the first time, its analog acetazolamide (ATZ), on specific Aβ-mediated pathways of mitochondrial dysfunction and apoptotic cell death. The CAIs selectively inhibited mitochondrial dysfunction pathways induced by Aβ, without affecting metabolic function. Due to the long-term use of MTZ and ATZ in chronic conditions, the efficacy and the safety of their systemic administration have been widely assessed, making clinical trials for CAIs ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Autophagy is a collection of several quality control processes in which broken cell components, damaged proteins, and metabolic waste are broken down and recycled. In the most familiar of these processes, the material to be recycled is wrapped in a membrane, an autophagosome, which then migrates to a lysosome, another membrane-bound organelle packed with enzymes capable of taking apart just about any molecule it is likely to encounter. Unfortunately, this recycling process falters with age in a number of ways, the consequences particularly apparent in very long-lived cells such as the neurons of the central nervous ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Internal vibrations, or internal tremors, are shaking sensations felt inside the body, and a person will often exhibit no visible movement. These tremors are associated with conditions such as Parkinson's disease and multiple sclerosis. In this article, learn about the causes and treatments of internal vibrations.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Neurology / Neuroscience Source Type: news
Internal vibrations, or internal tremors, are shaking sensations felt inside the body, and a person will often exhibit no visible movement. These tremors are associated with conditions such as Parkinson's disease and multiple sclerosis. In this article, learn about the causes and treatments of internal vibrations.
Source: Parkinson's Disease News From Medical News Today - Category: Neurology Tags: Neurology / Neuroscience Source Type: news
We read with great enthusiasm the article by Ferraz et  al, who demonstrated that 3 physical exercise modalities resulted in significant improvement of the walking capacity, ability to stand up and sit, and the functionality of patients with Parkinson disease (PD).1 Clearly, the authors demonstrated the beneficial effects of physical exercise programs and their significance as a complementary therapy for PD.
Source: Archives of Physical Medicine and Rehabilitation - Category: Rehabilitation Authors: Tags: Departments Source Type: research
(Peter the Great Saint-Petersburg Polytechnic University) Scientists from Peter the Great St. Petersburg Polytechnic University (SPbPU), participant of Russian Academic Excellence Initiative (Project 5-100) in collaboration with the Institute of Experimental Medicine and ITMO University developed a unique program which can determine a form of Parkinson's disease and predict possible future symptoms with the accuracy of up to 96 percent. According to the scientists, this development allows giving a person the required treatment as soon as possible.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
The somatosensory temporal discrimination threshold (STDT) measures a subject ’s ability to discriminate sensory stimuli in the temporal domain (Artieda et al. 1992; Conte et al. 2010; Tinazzi et al. 2013). Several studies have investigated the physiological mechanisms underlying the STDT in healthy subjects (Conte et al. 2012; Conte et al. 2017a; Lee et al. 2017; Leodori e t al. 2017; Rocchi et al. 2016). Findings from neurophysiological studies based on transcranial magnetic stimulation suggest that the STDT strongly relies on inhibitory interneurons in the primary somatosensory cortex (S1) (Antelmi et al.
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Source Type: research
In conclusion, our study showed that music elicits slightly altered emotional experiences in patients with and without STN DBS. In particular, STN DBS seems to induce less distinct emotional responses, blurring the boundaries between complex musical emotions.
Source: Neuropsychologia - Category: Neurology Source Type: research
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