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Altered bacterial communities in the gut could be an indicator for Parkinson's disease

Parkinson's disease is an insidious disease: by the time it manifests as the typical motor dysfunctions such as tremors or muscle rigidity, portions of the brain have already been irreversibly...
Source: Parkinson's Disease News From Medical News Today - Category: Neurology Tags: Parkinson's Disease Source Type: news

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The results of a decade-long study are in: a new therapeutic target is found, and scientists manage to slow the progression of the disease in animals.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Parkinson's Disease Source Type: news
AbstractThe blood-brain barrier and the intestinal barrier show signs of disruption in patients with idiopathic Parkinson ’s disease (PD) and animal models of nigrostriatal degeneration, and likewise in amyotrophic lateral sclerosis (ALS) models. A substantial body of evidence shows that defects in epithelial membrane barriers, both in the gut and within the cerebral vasculature, can result in increased vulnerability of tissues to external factors potentially participating in the pathogenesis of PD and ALS. As such, restoration of tissue barriers may prove to be a novel therapeutic target in neurodegenerative disease...
Source: Metabolic Brain Disease - Category: Neurology Source Type: research
Even relatively mild brain injuries may increase your risk of developing the neurodegenerative condition Parkinson’s disease, according to a new study. The research, which was published Wednesday in the journal Neurology, found a strong connection between traumatic brain injuries such as concussions and a heightened risk of Parkinson’s, regardless of the severity of the injuries. The findings specifically pertain to veterans whose data had been recorded in Veterans Health Administration databases between 2002 and 2014. Compared to those who had never suffered a TBI, the increase in Parkinson’s risk &mdash...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime Research Source Type: news
Authors: Müller T Abstract Heterogeneous expression of neurotransmitter deficits results from onset and progression of Parkinson's disease. Intervals, characterized by reappearance of motor and associated certain nonmotor symptoms, determine the end of good tolerability and efficacy of oral levodopa therapy. These "OFF" states result from levodopa pharmacokinetics and disease progression-related deterioration of the central buffering capacity for fluctuations of dopamine levels. This review discusses safinamide as an add-on therapeutic agent in orally levodopa-treated patients with "OFF" ph...
Source: Clinical Pharmacology: Advances and Applications - Category: Allergy & Immunology Tags: Clin Pharmacol Source Type: research
Source: Gait and Posture - Category: Orthopaedics Authors: Tags: Full length Article Source Type: research
Quantitative assessment of physical activities during daily life plays a significant role in evaluating the functional ability and the level of activity in healthy individuals and patients suffering from obesity, recurrent falling, Parkinson's disease, and back pain [1 –5]. In recent years, wearable inertial sensors with lightweight, long battery life, and large memory have become increasingly popular for ambulatory human motion analysis [6,7]. Najafi et al. [4,8] adopted the trunk inclination angle, obtained from the integration of the angular velocity and disc rete wavelet transform (DWT), to detect postural transi...
Source: Medical Engineering and Physics - Category: Biomedical Engineering Authors: Tags: Technical note Source Type: research
The presence of polysomnography-confirmed REM sleep behavior disorder (RBD) is the stronger risk factor for having prodromal Parkinson disease (PD), followed by abnormal presynaptic dopaminergic radionuclide neuroimaging. Aim of the review is to conduct a meta-analysis of literature data regarding presynaptic dopaminergic neuroimaging in RBD.A literature search was conducted, resulting in 16 papers that met the inclusion criteria. Clinical and neuroimaging data were extracted. The studies are heterogeneous, especially for neuroimaging methodology.
Source: Sleep Medicine Reviews - Category: Sleep Medicine Authors: Tags: Clinical Review Source Type: research
Conditions:   Pain;   Parkinson Disease Interventions:   Device: deep rTMS;   Device: placebo deep rTMS Sponsor:   University of Sao Paulo Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: A machine learning method for automated analysis of data from the Noldus Catwalk system was established. Significance: Our works shows the ability of machine learning to discriminate pharmacologically relevant animal groups based on their walking behavior in a multivariate manner. Further interesting aspects of the approach include the ability to learn from past experiments, improve with more data arriving and to make predictions for single animals in future studies.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
This article reviews recent studies at ultra-high field about Alzheimer’s disease (AD), Park inson’s disease (PD), and amyotrophic lateral sclerosis (ALS).Recent FindingsThe research on AD has mainly focused on detecting the thinning of hippocampal layers and the susceptibility effect supposed to be related to beta-amyloid deposition. In patients with PD, atypical parkinsonisms and subjects at risk of developing motor symptoms of Parkinson ’s disease, the main aim was to detect changes in the substantia nigra, probably related to increased iron deposition. In patients with ALS, both brain and spinal cord ...
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research
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