Altered bacterial communities in the gut could be an indicator for Parkinson's disease

Parkinson's disease is an insidious disease: by the time it manifests as the typical motor dysfunctions such as tremors or muscle rigidity, portions of the brain have already been irreversibly...
Source: Parkinson's Disease News From Medical News Today - Category: Neurology Tags: Parkinson's Disease Source Type: news

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Publication date: May 2019Source: Biomedical Signal Processing and Control, Volume 51Author(s): Pablo Rodríguez-Pérez, Rubén Fraile, Miguel García-Escrig, Nicolás Sáenz-Lechón, Juana M. Gutiérrez-Arriola, Víctor Osma-RuizAbstractA transversal study of the pitch variability of parkinsonian voices in read speech is presented. 30 patients suffering from Parkinson's disease (PD) and 32 healthy speakers were recorded while reading a text without voiceless phonemes. The fundamental frequency contours were calculated from the recordings, and the following measures wer...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
This study provides a possible reason why genes carrying health risks have persisted in human populations. The second found evidence for multiple variants in genes related to ageing that exhibited antagonistic pleiotropic effects. They found higher risk allele frequencies with large effect sizes for late-onset diseases (relative to early-onset diseases) and an excess of variants with antagonistic effects expressed through early and late life diseases. There also exists other recent tangible evidence of antagonistic pleiotropy in specific human genes. The SPATA31 gene has been found under strong positive genomic sele...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSION: Our study seems to reveal TNS is particularly effective on nocturia and urge. Moreover, nocturia and pollakiuria appear to be predictive factors for SNT compliance. Nocturia could be a prominent symptom in SNT's prescription. But studies with more patients should be conducted for obtain better patient selection in TNS. LEVEL OF EVIDENCE: IV. PMID: 30876700 [PubMed - as supplied by publisher]
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
Publication date: July 2019Source: Materials Science and Engineering: C, Volume 100Author(s): Jinhua Xue, Yutong Liu, Mohammad Ali Darabi, Genghong Tu, Lu Huang, Li Ying, Bin Xiao, Yue Wu, Malcolm Xing, Lin Zhang, Lu ZhangAbstractParkinson's disease (PD) is a long-term neurodegenerative disorders that characterized by a progressive loss of dopaminergic neurons in substantia nigra pars compacta (SNc). Bone marrow stromal cells (BMSCs) are promising therapeutic agents for neurodegenerative disease due to their multipotent capacity. To promote the potential therapeutic effect of BMSCs on PD, we developed an injectable Gelatin...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 11 January 2018Source: NeuroImageAuthor(s): Kamin Kim, Nicolaas I. Bohnen, Martijn L.T.M. Müller, Cindy LustigAbstractExecutive functions are complex both in the cognitive operations involved and in the neural structures and functions that support those operations. This complexity makes executive function highly vulnerable to the detrimental effects of aging, brain injury, and disease, but may also open paths to compensation. Neural compensation is often used to explain findings of additional or altered patterns of brain activations by older adults or patient populations compared to ...
Source: NeuroImage - Category: Neuroscience Source Type: research
Publication date: Available online 19 December 2017Source: NeuroImageAuthor(s): Yashar Zeighami, Seyed-Mohammad Fereshtehnejad, Mahsa Dadar, D. Louis Collins, Ronald B. Postuma, Bratislav Mišić, Alain DagherAbstractParkinson's disease (PD) is a neurodegenerative disorder characterized by a wide array of motor and non-motor symptoms. It remains unclear whether neurodegeneration in discrete loci gives rise to discrete symptoms, or whether network-wide atrophy gives rise to the unique behavioural and clinical profile associated with PD. Here we apply a data-driven strategy to isolate large-scale, multivariate associat...
Source: NeuroImage - Category: Neuroscience Source Type: research
Publication date: Available online 19 December 2017Source: NeuroImageAuthor(s): Kamin Kim, Martijn L.T.M. Müller, Nicolaas I. Bohnen, Martin Sarter, Cindy LustigAbstractPast animal and human studies robustly report that the cholinergic system plays an essential role in both top-down and bottom-up attentional control, as well as other aspects of cognition (see Ballinger et al., 2016 for a recent review). However, current understanding of how two major cholinergic pathways in the human brain (the basal forebrain-cortical pathway, and the brainstem pedunculopontine-thalamic pathway) contribute to specific cognitive ...
Source: NeuroImage - Category: Neuroscience Source Type: research
Publication date: August 2019Source: Journal of Neurolinguistics, Volume 51Author(s): Ece Bayram, Eda Aslanbaba, Muhittin Cenk AkbostanciAbstractParkinson's disease (PD) is associated with verb deficits detected with tasks including picture naming and verbal fluency. However, these deficits are not frequently reported by the patients themselves. Levodopa, the gold standard for motor symptoms in PD, has been previously implicated to improve these verb deficits. We evaluated the effect of levodopa by using a spontaneous speech task which is more naturalistic than the previously used tasks to detect verb deficits. Thirty PD p...
Source: Journal of Neurolinguistics - Category: Speech-Language Pathology Source Type: research
Conclusions: IGF1R, PRKACA, and lncRNA-XIST could be potentially involved in PD, and these diverse molecular mechanisms could support the development of the similar treatment for PD. PMID: 30867898 [PubMed]
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
Publication date: Available online 14 March 2019Source: The Lancet NeurologyAuthor(s): Valery L Feigin, Emma Nichols, Tahiya Alam, Marlena S Bannick, Ettore Beghi, Natacha Blake, William J Culpepper, E Ray Dorsey, Alexis Elbaz, Richard G Ellenbogen, James L Fisher, Christina Fitzmaurice, Giorgia Giussani, Linda Glennie, Spencer L James, Catherine Owens Johnson, Nicholas J Kassebaum, Giancarlo Logroscino, Benoît Marin, W Cliff Mountjoy-VenningSummaryBackgroundNeurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases...
Source: The Lancet Neurology - Category: Neurology Source Type: research
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