Compound regulates genetic risk factor in Parkinson's disease

Suchi Mittal and colleagues have identified beta-2 adrenergic receptor ( β2AR) agonists as compounds that can reduce levels of the alpha-synuclein gene, which has been implicated in increased risk...
Source: Parkinson's Disease News From Medical News Today - Category: Neurology Tags: Parkinson's Disease Source Type: news

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AbstractSpinocerebellar ataxia type 8 (SCA8) is a rare autosomal dominant neurodegenerative disease caused by expanded CTA/CTG repeats in theATXN8OS gene. Many patients had pure cerebellar ataxia, while some had parkinsonism, both without causal explanation. We analyzed theATXN8OS gene in 150 Japanese patients with ataxia and 76 patients with Parkinson ’s disease or related disorders. We systematically reassessed 123 patients with SCA8, both our patients and those reported in other studies. Two patients with progressive supranuclear palsy (PSP) had mutations in theATXN8OS gene. Systematic analyses revealed that patie...
Source: The Cerebellum - Category: Neurology Source Type: research
The parallel placebo-controlled study examined the therapeutic effects of dual-target repetitive transcranial magnetic stimulation (rTMS) of the motor cortex (bilaterally) and the left prefrontal cortex (dorsolaterally) on spontaneous and mitogen-stimulating synthesis of pro- and anti-inflammatory cytokines by the blood cells and the level of brain-derived neurotrophic factor (BDNF) in blood serum of patients with Parkinson ’s disease. The significantly steeper positive clinical dynamics (assessed by UPRSD scale) observed in rTMS group in comparison with the placebo group was accompanied by a significant drop in spon...
Source: Bulletin of Experimental Biology and Medicine - Category: Biology Source Type: research
This study highlights that, beyond the detrimental effects of tube feeding on quality of life, there could be detrimental effects from non-oral feeding on the health of our patients. This is obviously not the case for all patients, so each individual case needs to be considered, but these studies comparing outcomes are important to consider. Participant: When using the IDDSI (International Dysphagia Diet Standardization Initiative), are there at least two numbers included in a diet order: one for foods and one for liquids? Are dietary departments fully onboard? Rogus-Pulia: My understanding of IDDSI is that, yes,...
Source: American Speech-Language-Hearing Association (ASHA) Press Releases - Category: Speech-Language Pathology Authors: Tags: Academia & Research Health Care Private Practice Slider Speech-Language Pathology Dysphagia Feeding Disorders nutrition Speech Disorders Swallowing Disorders Source Type: blogs
Patients with moderate to advanced Parkinson's disease exhibit higher glucose levels than healthy controls during glucose tolerance testing, without the expected rise of insulin.Medscape Medical News
Source: Medscape Pathology Headlines - Category: Pathology Tags: Neurology & Neurosurgery News Source Type: news
(MedPage Today) -- In phase Ib trial, investigational mAb targets aggregated alpha-synuclein
Source: MedPage Today Neurology - Category: Neurology Source Type: news
Former Pennsylvania Gov. Ed Rendell says he has been diagnosed with Parkinson's disease
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
We describe a case of unilateral acne which appeared after an episode of facial nerve palsy. An 18-year-old female patient presented with papules and pustules predominantly located on the side where the facial paralysis occurred. The patient suffered right facial paralysis, which was treated with prednisone and kinesiotherapy with massages, electrostimulation, and infrared light. Two weeks later, acne lesions appeared in the area affected by the paralysis. As suggested in other cases of paralysis, including cases of Parkinson ’ s disease and spinal cord injury, an increased sebum excretion rate and the immobility of ...
Source: Anais Brasileiros de Dermatologia - Category: Dermatology Source Type: research
The phase 1 clinical trial involved an antibody targeting the alpha-synuclein protein, which scientists believe causes specific brain cells to die in patients with Parkinson ’s disease, which affects 1.5 million people in the U.S.
Source: Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
OBJECTIVE: To identify the phenomenological features and neural correlates of visual illusions in Parkinson's disease (PD). METHODS: Ninety-three patients with PD were assessed via questionnaires regarding visual illusions and behavioral symptoms, ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news
ConclusionCAMs, especially Chinese materia medica, rehabilitation exercise, and acupuncture, are widely used for PD patients in China.
Source: Chinese Journal of Integrative Medicine - Category: Internal Medicine Source Type: research
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