Compound regulates genetic risk factor in Parkinson's disease

Suchi Mittal and colleagues have identified beta-2 adrenergic receptor ( β2AR) agonists as compounds that can reduce levels of the alpha-synuclein gene, which has been implicated in increased risk...
Source: Parkinson's Disease News From Medical News Today - Category: Neurology Tags: Parkinson's Disease Source Type: news

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Paulina Troncoso-Escudero, Alejandra Parra, Melissa Nassif, Rene L. Vidal
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Authors: Altimus CM, Keller K, Brannelly P, Ross E, Lin CT, Riley EAU, Briggs L, Smith J, Stevens M Abstract Neurodegenerative diseases encompass a range of diagnoses, such as Alzheimer's disease and Parkinson's disease. Despite decades of advancements in understanding the neurobiology of individual diseases, this class has few disease-modifying therapeutics and a paucity of biomarkers for diagnosis or progression. However, tau protein aggregation has emerged as a potential unifying factor across several neurodegenerative diseases, which has prompted a rapid growth in tau-related funding. In spite of this growth, r...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
AbstractEnd-of-dose motor fluctuations are regarded as one of the core troublesome symptoms by patients with Parkinson ’s disease (PD). Treatment of levodopa (l-dopa)-induced motor fluctuations is still an unmet medical need.l-dopa is the gold standard in the treatment of motor PD symptoms; notwithstanding, a wide range of adjunct therapies are currently available for the treatment of end-of-dose motor fluctuations. Additionally, device-aided therapies, such as deep brain stimulation,l-dopa-carbidopa intestinal gel infusion, and on-demand injection or continuous apomorphine infusion, may be considered when oral treat...
Source: Drugs and Aging - Category: Geriatrics Source Type: research
Authors: Zella MAS, May C, Müller T, Ahrens M, Tönges L, Gold R, Marcus K, Woitalla D Abstract BACKGROUND/AIMS: Pain is a non-motor symptom of Parkinson's disease (PD). Few systematic studies have been carried out and there are still no guidelines on pain therapy in PD. Additionally, within the studies that do exist, gender-specific differences in pain perception are often the focus, though no consistent results have to date been obtained. The first main aim of our study was therefore to map pain in the largest PD study group to date, with the second being the analysis of the impact of different pain ther...
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
Authors: Karlstedt M, Fereshtehnejad SM, Aarsland D, Lökk J Abstract The relationship quality, mutuality, has been identified as a protective factor in family care situations, but its role in mediating health-related quality of life (HRQoL) in patients having Parkinson's disease (PD) is not known. Data on patients' and partners' mutuality (MS), motor signs (UPDRS III), non-motor symptoms (NMSQuest), impaired cognition (IQCODE), dependency in activities of daily life (ADL), and HRQoL (PDQ8) were collected from 51 dyads. Structural equation model with manifest variables was applied to explore if the MS score med...
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
Publication date: Available online 12 October 2018Source: International Review of NeurobiologyAuthor(s): Michele Matarazzo, Daryl Wile, Melissa Mackenzie, A. Jon StoesslAbstractMost cases of Parkinson's disease (PD) are idiopathic, but some characteristics, such as early onset for a positive family history, raise suspicions of an inherited form of the disease. In the last decades several genes have been linked to parkinsonism, with different patterns of inheritance and different clinical phenotypes. Positron emission tomography (PET) imaging has helped to characterize genetic-linked parkinsonism, thanks to the availability...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Fighting Parkinson's … and Winning: A memoir of my recovery from Parkinson's Disease. Issues Ment Health Nurs. 2018 Oct 10;:1 Authors: Roman MW PMID: 30303696 [PubMed - as supplied by publisher]
Source: Issues in Mental Health Nursing - Category: Nursing Tags: Issues Ment Health Nurs Source Type: research
Better awareness of the cognitive domains affected in non-demented Parkinson's Disease (PD) should improve understanding of cognitive disease mechanisms. A complete understanding of the cognitive areas impaired in non-demented PD is hindered because most studies use small clinical samples without comparison to healthy controls. This meta-analysis examined cumulative evidence across studies to determine if there were impairments in non-demented PD in the three cognitive domains thought to be most widely affected in PD: frontal executive, visuospatial, and verbal memory.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Review article Source Type: research
In this study it is intended to detect the f requency threshold and the minimum interval of perception of the vibrotactile feedback, through a proposed wearable system, a waistband. Experimental tests were carried out that considered a temporal, spatial and spatiotemporal context, for which 15 healthy and 15 PD patients participated. It was de tected as threshold frequency 180 Hz and for minimum interval of vibration perception 250 ms. The identification of this threshold frequency and this interval will allow us to select the frequency and the minimum interval of vibration to be used in a Vibrotactile Biofeedbac...
Source: Journal of Medical Systems - Category: Information Technology Source Type: research
ConclusionThese findings indicate that KRG may have therapeutic potential for the treatment of patients with PD.
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research
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