Parkinson's: Sniff test could predict risk up to a decade earlier
New study suggests that a test of olfaction could determine a person's risk of developing Parkinson's disease up to 10 years before a diagnosis.
(MedPage Today) -- Associations persisted up to 2 decades after exposure
WASHINGTON (Reuters) - The U.S. Food and Drug Administration said on Wednesday it was reviewing Acadia Pharmaceuticals' Parkinson's medication, the only approved drug used to treat hallucinations and delusions associated with the disease.
Inflammatory bowel disease raises the risk for Parkinson's disease, but anti-TNF therapy may reduce the risk, researchers report.Medscape Medical News
WEDNESDAY, April 25, 2018 -- Patients with inflammatory bowel disease (IBD) have increased incidence of Parkinson's disease (PD), which is attenuated with anti-tumor necrosis factor (TNF) therapy, according to a study published online April 23 in...
WASHINGTON, DC - MRI scans with a diffusion-tensor imaging protocol (DTI-MRI)...Read more on AuntMinnie.comRelated Reading: DTI-MRI finds abnormal brain connections in autistic kids DTI-MRI ties lack of fitness to cognitive decline Court rules that DTI-MRI scans are not 'junk science' DTI-MRI poses new cause for schizophrenia DTI-MRI sheds light on Parkinson's disease
AbstractOral administration of levodopa (LD) is the gold standard in managing Parkinson ’s disease (PD). Although LD is the most effective drug in treating PD, chronic administration of LD induces levodopa-induced dyskinesia. A continuous and sustained provision of LD to the brain could, therefore, reduce peak-dose dyskinesia. In commercial oral formulations, LD is co-administrated w ith an AADC inhibitor (carbidopa) and a COMT inhibitor (entacapone) to enhance its bioavailability. Nevertheless, patients are known to take up to five tablets a day because of poor sustained-releasing capabilities that lead to fluctuati...
Olfactory dysfunction has been established as a frequent non-motor symptom in neurodegenerative and movement disorders such as Parkinson's disease, Alzheimer's disease, and hereditary ataxias. To expand knowledge of non-motor symptoms in dystonia, and to test for a potential endophenotype, we examined olfactory function in cervical dystonia (CD).
ConclusionsMean diffusivity represents an important correlate of cognitive function and predictor of motor impairment in Parkinson ’s disease: DTI is potentially a useful tool in stratification of patients into clinical trials and to monitor the impact of treatment on motor function.
Publication date: 29 May 2018 Source:Neuroscience Letters, Volume 676 Author(s): Peng Wang, Yi Guo, Chengyuan Song, Yiming Liu, Hao Deng Parkinson’s disease (PD) features selective loss of dopaminergic neurons of the substantia nigra pars compacta accompanied by the accumulation and aggregation of alpha-synuclein in Lewy bodies. PTEN induced putative kinase 1 gene (PINK1) mutations are the second most common genetic cause of autosomal recessive early-onset Parkinson’s disease (EOPD). A single nucleotide deletion in PINK1 exon 8 (c.1557delG) was identified in a consanguineous Chinese family with EOPD. The homoz...