Human neutrophils show decreased survival upon long ‐term exposure to clozapine
ConclusionsThe effect of long‐term exposure to clozapine on neutrophil survival is plausibly associated with delayed onset of agranulocytosis after initial exposure. Our results suggest that human neutrophils are vulnerable to clozapine and its reactive metabolite in a concentration‐ and time‐dependent manner.
Source: Human Psychopharmacology: Clinical and Experimental - Category: Psychiatry Authors: Aya Goto, Akira Yoshimi, Tomoko Nagai, Mako Ukigai, Akihiro Mouri, Norio Ozaki, Yukihiro Noda Tags: RESEARCH ARTICLE Source Type: research