Human neutrophils show decreased survival upon long ‐term exposure to clozapine

ConclusionsThe effect of long‐term exposure to clozapine on neutrophil survival is plausibly associated with delayed onset of agranulocytosis after initial exposure. Our results suggest that human neutrophils are vulnerable to clozapine and its reactive metabolite in a concentration‐ and time‐dependent manner.
Source: Human Psychopharmacology: Clinical and Experimental - Category: Psychiatry Authors: Tags: RESEARCH ARTICLE Source Type: research