The innate immune receptor MDA5 limits rotavirus infection but promotes cell death and pancreatic inflammation

Melanoma differentiation-associated protein 5 (MDA5) mediates the innate immune response to viral infection. Polymorphisms in IFIH1, the gene coding for MDA5, correlate with the risk of developing type 1 diabetes (T1D). Here, we demonstrate that MDA5 is crucial for the immune response to enteric rotavirus infection, a proposed etiological agent for T1D. MDA5 variants encoded by minor IFIH1 alleles associated with lower T1D risk exhibit reduced activity against rotavirus infection. We find that MDA5 activity limits rotavirus infection not only through the induction of antiviral interferons and pro-inflammatory cytokines, but also by promoting cell death. Importantly, this MDA5-dependent antiviral response is specific to the pancreas of rotavirus-infected mice, similar to the autoimmunity associated with T1D. These findings imply that MDA5-induced cell death and inflammation in the pancreas facilitate progression to autoimmune destruction of pancreatic β-cells.
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Immunology, Molecular Biology of Disease Articles Source Type: research

Related Links:

(CNN) — Your social media could reveal a lot more about you than you think. Say, for example, whether you have a medical condition. In a new study, researchers were able to predict 21 types of medical conditions — ranging from pregnancy to skin disorders — by analyzing people’s Facebook profiles. Facebook status updates were “particularly effective at predicting diabetes and mental health conditions including anxiety, depression and psychoses,” the study found. The study will be published June 19 in PLOS One, a peer-reviewed open access scientific journal published since 2006 “Peop...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Offbeat CNN Facebook Source Type: news
The D2d trial showed that vitamin D supplementation does not prevent type 2 diabetes in those at risk. Drs Pittas and Shubrook discuss what else we can learn from this trial.Medscape Diabetes &Endocrinology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology Commentary Source Type: news
DiabetesMine covers an array of new diabetes research presented at the American Diabetes Association's Scientific Sessions in early June 2019.
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs
ConclusionExperimental validation of network analysis revealed anti-diabetic effects of the plant product SGD, manifested most notably by improved serum profiles and diminished insulin resistance. These experimental results may have clinical implications.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Abstract We hypothesize that, ancestrally, sex-specific immune modulation evolved to facilitate survival of the pregnant person in the presence of an invasive placenta and an immunologically challenging pregnancy - an idea we term the 'pregnancy compensation hypothesis' (PCH). Further, we propose that sex differences in immune function are mediated, at least in part, by the evolution of gene content and dosage on the sex chromosomes, and are regulated by reproductive hormones. Finally, we propose that changes in reproductive ecology in industrialized environments exacerbate these evolved sex differences, resulting...
Source: Trends in Genetics : TIG - Category: Genetics & Stem Cells Authors: Tags: Trends Genet Source Type: research
In cardiovascular outcomes trials for type 2 diabetes drugs, data weren't significant for benefit among the small number of black and African American participants.Medscape Medical News
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Diabetes & Endocrinology News Source Type: news
BOSTON (CBS) — It’s that time of year: kids are heading off to camp and the American Academy of Pediatrics is updating its recommendations on how to keep kids safe during the summer. First, all campers should have a pre-camp check-up with their pediatrician to address any health issues and update immunizations, whether it’s a day camp or an overnight camp. The AAP also suggested parents communicate directly with camp administrators to discuss any special health concerns, like food safety if a child has food allergies, or how daily medications will be stored and administered for kids who have underlying he...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Healthwatch Seen On WBZ-TV Syndicated Local American Academy Of Pediatrics Dr. Mallika Marshall Summer Camp Source Type: news
Lupus is an autoimmune disease that causes a wide variety of symptoms. In this article, see pictures of lupus symptoms and learn more about the different types of this condition.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Lupus Source Type: news
New Jersey’s largest health insurer has partnered with a biopharma vendor to optimize drug treatment using medical and pharmacy claims data.  Horizon Healthcare Services will work with vendor Aetion to support case management strategies and develop value-based agreements with pharmas targeting specific patient populations. Aetion is in the business of providing payers and biopharma companies […]
Source: EMR and HIPAA - Category: Information Technology Authors: Tags: Ambulatory Analytics/Big Data Clinical Healthcare IT Hospital - Health System Aetion AstraZeneca Boehringer Ingelheim Eli Lilly and Company Geisinger Horizon Healthcare Services Type 2 Diabetes UPMC Health Plan Value-Based Contra Source Type: blogs
- Afinion ™ HbA1c Dx test provides results in three minutes, enabling clinicians to develop informed, individualized care plans during patient consultation
Source: Abbott.com - Category: Pharmaceuticals Source Type: news
More News: Allergy & Immunology | Autoimmune Disease | Biology | Diabetes | Diabetes Type 1 | Endocrinology | Genetics | Melanoma | Molecular Biology | Pancreas | Rotavirus | Skin Cancer