Adipogenic Effects and Gene Expression Profiling of Firemaster ® 550 Components in Human Primary Preadipocytes

Conclusions:
We found that FM550, and two of its components, induced adipogenesis in human primary preadipocytes. Further, using global gene expression analysis we showed that both TPP and IPTP likely exert their effects through PPARG to induce adipogenesis. In addition, IPTP perturbed signaling pathways that were not affected by TPP. https://doi.org/10.1289/EHP1318

Received: 02 November 2016
Revised: 18 May 2017
Accepted: 23 May 2017
Published: 14 September 2017
Address correspondence to E. Atlas, Environmental Health Science and Research Bureau, Health Canada, 50 Colombine Driveway, Ottawa, Ontario, K1A 0K9, Canada. Telephone: [phone]. Email: [e-mail]
Supplemental Material is available online (https://doi.org/10.1289/EHP1318).
The authors declare they have no actual or potential competing financial interests.
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Source: EHP Research - September 15, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research